MCFD_DICDI
ID MCFD_DICDI Reviewed; 344 AA.
AC Q55E85;
DT 13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Mitochondrial substrate carrier family protein D;
GN Name=mcfD; ORFNames=DDB_G0269352;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP REVIEW.
RX PubMed=17442478; DOI=10.1016/j.biochi.2007.03.004;
RA Satre M., Mattei S., Aubry L., Gaudet P., Pelosi L., Brandolin G.,
RA Klein G.;
RT "Mitochondrial carrier family: repertoire and peculiarities of the cellular
RT slime mould Dictyostelium discoideum.";
RL Biochimie 89:1058-1069(2007).
CC -!- FUNCTION: Calcium-dependent mitochondrial solute carrier. Mitochondrial
CC solute carriers shuttle metabolites, nucleotides, and cofactors through
CC the mitochondrial inner membrane (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000005; EAL72026.1; -; Genomic_DNA.
DR RefSeq; XP_645896.1; XM_640804.1.
DR AlphaFoldDB; Q55E85; -.
DR SMR; Q55E85; -.
DR STRING; 44689.DDB0237604; -.
DR PaxDb; Q55E85; -.
DR EnsemblProtists; EAL72026; EAL72026; DDB_G0269352.
DR GeneID; 8616838; -.
DR KEGG; ddi:DDB_G0269352; -.
DR dictyBase; DDB_G0269352; mcfD.
DR eggNOG; KOG0758; Eukaryota.
DR HOGENOM; CLU_015166_16_1_1; -.
DR InParanoid; Q55E85; -.
DR OMA; IFWLTSY; -.
DR PhylomeDB; Q55E85; -.
DR Reactome; R-DDI-70635; Urea cycle.
DR PRO; PR:Q55E85; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0000064; F:L-ornithine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:1990575; P:mitochondrial L-ornithine transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..344
FT /note="Mitochondrial substrate carrier family protein D"
FT /id="PRO_0000385520"
FT TOPO_DOM 1..22
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250"
FT TRANSMEM 23..43
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 44..75
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250"
FT TRANSMEM 76..96
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 97..116
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250"
FT TRANSMEM 117..137
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 138..186
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250"
FT TRANSMEM 187..207
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 208..238
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250"
FT TRANSMEM 239..259
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..301
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250"
FT TRANSMEM 302..321
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 322..344
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250"
FT REPEAT 17..104
FT /note="Solcar 1"
FT REPEAT 119..212
FT /note="Solcar 2"
FT REPEAT 239..327
FT /note="Solcar 3"
SQ SEQUENCE 344 AA; 37959 MW; 20388998A22D03AD CRC64;
MDSTKTNNKW AAAGILNSVG KDFVAGSVGG MSSIMAGHPF DTIKVMLQDA SGNLPKFKNG
FQALKYIMKV DGIKGIYRGL SVPLFSVSFT NSVFFATNNF CQSYFHPPCK DENGEDILIP
YHKAAAAGAI AGGVISLLIT PRDLVKSKLQ VQCRPFGSTN VSLQYKGPID VIRQTIKRDG
IKGMFKGIRS TFCRDIPGDA VYFVVYEFMK RKLLALSKNN NNNNNNNDNN DNSSPKAGVP
AWVAIGAGGC AGMSFWMSIY PMDVVKTRIQ TQPDHLPPQY TSVLQTITKI YREEGISVFF
RGFSATILRA FPTSAVNFLM YETTRNLLNS KDPFYNNNDH YNAE
