ID   MCFG_DICDI              Reviewed;         300 AA.
AC   Q54BM3;
DT   13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Mitochondrial substrate carrier family protein G;
DE   AltName: Full=Solute carrier family 25 member 20 homolog A;
GN   Name=mcfG; Synonyms=slc25a20A; ORFNames=DDB_G0293556;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2]
RP   REVIEW.
RX   PubMed=17442478; DOI=10.1016/j.biochi.2007.03.004;
RA   Satre M., Mattei S., Aubry L., Gaudet P., Pelosi L., Brandolin G.,
RA   Klein G.;
RT   "Mitochondrial carrier family: repertoire and peculiarities of the cellular
RT   slime mould Dictyostelium discoideum.";
RL   Biochimie 89:1058-1069(2007).
RN   [3]
RP   INDUCTION [LARGE SCALE ANALYSIS].
RX   PubMed=18559084; DOI=10.1186/1471-2164-9-291;
RA   Sillo A., Bloomfield G., Balest A., Balbo A., Pergolizzi B., Peracino B.,
RA   Skelton J., Ivens A., Bozzaro S.;
RT   "Genome-wide transcriptional changes induced by phagocytosis or growth on
RT   bacteria in Dictyostelium.";
RL   BMC Genomics 9:291-291(2008).
CC   -!- FUNCTION: Mitochondrial solute carriers shuttle metabolites,
CC       nucleotides, and cofactors through the mitochondrial inner membrane.
CC       Mediates the transport of acylcarnitines of different length across the
CC       mitochondrial inner membrane from the cytosol to the mitochondrial
CC       matrix for their oxidation by the mitochondrial fatty acid-oxidation
CC       pathway (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- INDUCTION: Up-regulated by phagocytic stimuli.
CC       {ECO:0000269|PubMed:18559084}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000218; EAL60590.1; -; Genomic_DNA.
DR   RefSeq; XP_629006.1; XM_629004.1.
DR   AlphaFoldDB; Q54BM3; -.
DR   SMR; Q54BM3; -.
DR   STRING; 44689.DDB0237597; -.
DR   PaxDb; Q54BM3; -.
DR   EnsemblProtists; EAL60590; EAL60590; DDB_G0293556.
DR   GeneID; 8629290; -.
DR   KEGG; ddi:DDB_G0293556; -.
DR   dictyBase; DDB_G0293556; mcfG.
DR   eggNOG; KOG0758; Eukaryota.
DR   HOGENOM; CLU_015166_16_1_1; -.
DR   InParanoid; Q54BM3; -.
DR   OMA; YGVWFLA; -.
DR   PhylomeDB; Q54BM3; -.
DR   PRO; PR:Q54BM3; -.
DR   Proteomes; UP000002195; Chromosome 6.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   Gene3D; 1.50.40.10; -; 2.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   Pfam; PF00153; Mito_carr; 3.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Repeat; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..300
FT                   /note="Mitochondrial substrate carrier family protein G"
FT                   /id="PRO_0000385522"
FT   TOPO_DOM        1..9
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        10..30
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        31..72
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        73..93
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        94..115
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        116..136
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        137..168
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        169..190
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        191..211
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        212..232
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        233..272
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        273..292
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        293..300
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000250"
FT   REPEAT          11..98
FT                   /note="Solcar 1"
FT   REPEAT          110..197
FT                   /note="Solcar 2"
FT   REPEAT          209..298
FT                   /note="Solcar 3"
SQ   SEQUENCE   300 AA;  32112 MW;  63A6D083F6762872 CRC64;
     MASNNKDSQL MIALKDIVAG SIGGVGQVFT GHPLDTIKVR LQTQSVGNPI YSGTMDCLKK
     TISQEGFAGL YKGVASPLVG LSIMNSVMFL AYGQSKTLIQ KLSDNPNEAL DLKGLTAAGA
     LAGIAIGFVD APVDLFKSQM QVQQGDKNQY KSTADCAKQI WKVGGVRGVF QGLGATLVRD
     IPANACYFGA YELCRDFLAS KDNISVNQLS SLQIMAAGGA GGVSYWTLTY PADVVKSTMQ
     TDAIVKSQRK YKNMIDCASK IYKQQGIAGF YKGFTPCFIR SVPANAACFV LYEKARQIMS