MCFJ_DICDI
ID MCFJ_DICDI Reviewed; 345 AA.
AC Q54VX4;
DT 13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 94.
DE RecName: Full=Mitochondrial substrate carrier family protein J;
GN Name=mcfJ; ORFNames=DDB_G0280083;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP REVIEW.
RX PubMed=17442478; DOI=10.1016/j.biochi.2007.03.004;
RA Satre M., Mattei S., Aubry L., Gaudet P., Pelosi L., Brandolin G.,
RA Klein G.;
RT "Mitochondrial carrier family: repertoire and peculiarities of the cellular
RT slime mould Dictyostelium discoideum.";
RL Biochimie 89:1058-1069(2007).
RN [3]
RP INDUCTION [LARGE SCALE ANALYSIS].
RX PubMed=18559084; DOI=10.1186/1471-2164-9-291;
RA Sillo A., Bloomfield G., Balest A., Balbo A., Pergolizzi B., Peracino B.,
RA Skelton J., Ivens A., Bozzaro S.;
RT "Genome-wide transcriptional changes induced by phagocytosis or growth on
RT bacteria in Dictyostelium.";
RL BMC Genomics 9:291-291(2008).
CC -!- FUNCTION: Mitochondrial solute carriers shuttle metabolites,
CC nucleotides, and cofactors through the mitochondrial inner membrane.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- INDUCTION: Up-regulated by phagocytic stimuli.
CC {ECO:0000269|PubMed:18559084}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000035; EAL67268.1; -; Genomic_DNA.
DR RefSeq; XP_641231.1; XM_636139.1.
DR AlphaFoldDB; Q54VX4; -.
DR STRING; 44689.DDB0237610; -.
DR PaxDb; Q54VX4; -.
DR EnsemblProtists; EAL67268; EAL67268; DDB_G0280083.
DR GeneID; 8622362; -.
DR KEGG; ddi:DDB_G0280083; -.
DR dictyBase; DDB_G0280083; mcfJ.
DR eggNOG; KOG0765; Eukaryota.
DR HOGENOM; CLU_015166_3_3_1; -.
DR InParanoid; Q54VX4; -.
DR OMA; RGFMINT; -.
DR PhylomeDB; Q54VX4; -.
DR PRO; PR:Q54VX4; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..345
FT /note="Mitochondrial substrate carrier family protein J"
FT /id="PRO_0000385524"
FT TOPO_DOM 1..31
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250"
FT TRANSMEM 32..52
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 53..88
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250"
FT TRANSMEM 89..110
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 111..129
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250"
FT TRANSMEM 130..150
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 151..191
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250"
FT TRANSMEM 192..208
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 209..257
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250"
FT TRANSMEM 258..278
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 279..316
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250"
FT TRANSMEM 317..337
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 338..345
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250"
FT REPEAT 30..118
FT /note="Solcar 1"
FT REPEAT 129..217
FT /note="Solcar 2"
FT REPEAT 255..342
FT /note="Solcar 3"
SQ SEQUENCE 345 AA; 39012 MW; 90474674C4D87661 CRC64;
MSSSHTIQET KEVHTKTNKR IQWDDLDPKR YYFYNFLLGG SIDLLMFPLD VIRTRLQVQG
SQNVIQSFPQ YNGTFDGFKK LIRLEGKRAL YKGFLTSECG YLCSRAIYFG SYEFVKQGFL
KGRSDSDSDL LFVTTISGAI SEALASVIWV PFDVATQSVQ IQGSLSKPKY KGGSDVFKKI
YGERGIKGLY KGFGATIIRN VPYSGIWWGT YEISKSKLTQ FNIRQKLGLK ERSSHSLAVS
AEIDKNNPSH EVENEDPIIH FISGFFAAVF ATSITNPLDV AKTRLQTGVF PENEKPNFYT
IIKSTIRKEG IRALWKGLVP SLLTSTPYSM ISIFLYEEVK KLSLK
