MCFM_DICDI
ID MCFM_DICDI Reviewed; 306 AA.
AC Q54QN2;
DT 13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Mitochondrial substrate carrier family protein M;
DE AltName: Full=Solute carrier family 25 member 32 homolog;
GN Name=mcfM; Synonyms=slc25a32; ORFNames=DDB_G0283751;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP REVIEW.
RX PubMed=17442478; DOI=10.1016/j.biochi.2007.03.004;
RA Satre M., Mattei S., Aubry L., Gaudet P., Pelosi L., Brandolin G.,
RA Klein G.;
RT "Mitochondrial carrier family: repertoire and peculiarities of the cellular
RT slime mould Dictyostelium discoideum.";
RL Biochimie 89:1058-1069(2007).
CC -!- FUNCTION: Mitochondrial solute carriers shuttle metabolites,
CC nucleotides, and cofactors through the mitochondrial inner membrane.
CC Transports folate across the inner membranes of mitochondria (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000056; EAL65642.1; -; Genomic_DNA.
DR RefSeq; XP_638991.1; XM_633899.1.
DR AlphaFoldDB; Q54QN2; -.
DR SMR; Q54QN2; -.
DR PaxDb; Q54QN2; -.
DR EnsemblProtists; EAL65642; EAL65642; DDB_G0283751.
DR GeneID; 8624237; -.
DR KEGG; ddi:DDB_G0283751; -.
DR dictyBase; DDB_G0283751; mcfM.
DR eggNOG; KOG0764; Eukaryota.
DR HOGENOM; CLU_015166_6_4_1; -.
DR InParanoid; Q54QN2; -.
DR OMA; TYELIVC; -.
DR PhylomeDB; Q54QN2; -.
DR PRO; PR:Q54QN2; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0015230; F:FAD transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0008517; F:folic acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:1904947; P:folate import into mitochondrion; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR InterPro; IPR044712; SLC25A32-like.
DR PANTHER; PTHR45683; PTHR45683; 1.
DR Pfam; PF00153; Mito_carr; 3.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..306
FT /note="Mitochondrial substrate carrier family protein M"
FT /id="PRO_0000385533"
FT TOPO_DOM 1..10
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250"
FT TRANSMEM 11..31
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 32..72
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250"
FT TRANSMEM 73..89
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 90..113
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250"
FT TRANSMEM 114..134
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 135..163
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250"
FT TRANSMEM 164..184
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 185..211
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250"
FT TRANSMEM 212..232
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 233..278
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250"
FT TRANSMEM 279..296
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 297..306
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250"
FT REPEAT 5..98
FT /note="Solcar 1"
FT REPEAT 108..195
FT /note="Solcar 2"
FT REPEAT 207..299
FT /note="Solcar 3"
SQ SEQUENCE 306 AA; 34343 MW; B728874AA7D85146 CRC64;
MRYILNNNVE GTSALLGSTV ATAFLQPFDF LKIRLQGSGF ASGGDLNKFK RVGVIDTCKN
VLKNEGIKQF WRGSSPTIVA SGIAWGTYMH FYEAYKNILK SKYNVTQLNT FDHFICAVGA
SATQVFITNP IFLIKTRMQL QTPGSANYYT GIFDGIKKTV KVEGFKGLYK GVIPSLWLTF
HGGIQMSSYE HIKFYFSSNS GKSLDSLNAS EIFIASSISK FLASTILYPF QVVKTRLQDE
RNIPNQNNVR VYNGTKDVIF KILKNEGIIG FYRGLVPNTL KVIPNTSITL LLYEEIKKSF
NYIINE
