MCFR_DICDI
ID MCFR_DICDI Reviewed; 326 AA.
AC Q54QI8;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 104.
DE RecName: Full=Mitochondrial substrate carrier family protein R;
DE AltName: Full=Solute carrier family 25 member 16 homolog B;
GN Name=mcfR; Synonyms=slc25a16B; ORFNames=DDB_G0283811;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP REVIEW.
RX PubMed=17442478; DOI=10.1016/j.biochi.2007.03.004;
RA Satre M., Mattei S., Aubry L., Gaudet P., Pelosi L., Brandolin G.,
RA Klein G.;
RT "Mitochondrial carrier family: repertoire and peculiarities of the cellular
RT slime mould Dictyostelium discoideum.";
RL Biochimie 89:1058-1069(2007).
CC -!- FUNCTION: Mitochondrial solute carriers shuttle metabolites,
CC nucleotides, and cofactors through the mitochondrial inner membrane.
CC May be involved in the accumulation of coenzyme A in the mitochondrial
CC matrix (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000057; EAL65520.1; -; Genomic_DNA.
DR RefSeq; XP_638883.1; XM_633791.1.
DR AlphaFoldDB; Q54QI8; -.
DR SMR; Q54QI8; -.
DR PaxDb; Q54QI8; -.
DR EnsemblProtists; EAL65520; EAL65520; DDB_G0283811.
DR GeneID; 8624281; -.
DR KEGG; ddi:DDB_G0283811; -.
DR dictyBase; DDB_G0283811; mcfR.
DR eggNOG; KOG0752; Eukaryota.
DR HOGENOM; CLU_015166_10_1_1; -.
DR InParanoid; Q54QI8; -.
DR OMA; FYFYETM; -.
DR PhylomeDB; Q54QI8; -.
DR Reactome; R-DDI-196783; Coenzyme A biosynthesis.
DR PRO; PR:Q54QI8; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015228; F:coenzyme A transmembrane transporter activity; ISS:dictyBase.
DR GO; GO:0015880; P:coenzyme A transport; ISS:dictyBase.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..326
FT /note="Mitochondrial substrate carrier family protein R"
FT /id="PRO_0000329430"
FT TRANSMEM 12..32
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 64..84
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..124
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 185..205
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 226..246
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 290..310
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 9..95
FT /note="Solcar 1"
FT REPEAT 101..214
FT /note="Solcar 2"
FT REPEAT 226..318
FT /note="Solcar 3"
SQ SEQUENCE 326 AA; 35861 MW; 8B2A96B7A147C77A CRC64;
MTVHGNTKTS PMVTLLAGGV SGVIAKSTIA PLERVKILYQ VKSKMYSFNS VYGLMKNIIK
NEGLAGLWKG NTATILRIFP YSAIQWTSYD YLKNNFVTDK KSSVQIFIAG SLGFSCAILL
TYPLDVIRAR LALSYSNNNN NNSINSKNLN SSTQPPKVLK NGIGAVNIEK SIDFNGYKTK
GLFKGIWRGI LPTLYGSIPY AGVGYSSFEY FKRIAPDSFR NEKGDVIGIY KLISGGVAGG
LGQTAAYPLD VVRRRIQTTG YGDGKGVENL KHSTLKTMFT IFQKEGIYAL FKGISINYIK
VIPTNGVAFL TYETLCDYFN SKLNKN
