MCFU_DICDI
ID MCFU_DICDI Reviewed; 390 AA.
AC Q54S10;
DT 13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 94.
DE RecName: Full=Mitochondrial substrate carrier family protein U;
GN Name=mcfU; ORFNames=DDB_G0282727;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP REVIEW.
RX PubMed=17442478; DOI=10.1016/j.biochi.2007.03.004;
RA Satre M., Mattei S., Aubry L., Gaudet P., Pelosi L., Brandolin G.,
RA Klein G.;
RT "Mitochondrial carrier family: repertoire and peculiarities of the cellular
RT slime mould Dictyostelium discoideum.";
RL Biochimie 89:1058-1069(2007).
CC -!- FUNCTION: Mitochondrial solute carriers shuttle metabolites,
CC nucleotides, and cofactors through the mitochondrial inner membrane.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000047; EAL66223.1; -; Genomic_DNA.
DR RefSeq; XP_640229.1; XM_635137.1.
DR AlphaFoldDB; Q54S10; -.
DR SMR; Q54S10; -.
DR STRING; 44689.DDB0234110; -.
DR PaxDb; Q54S10; -.
DR EnsemblProtists; EAL66223; EAL66223; DDB_G0282727.
DR GeneID; 8623769; -.
DR KEGG; ddi:DDB_G0282727; -.
DR dictyBase; DDB_G0282727; mcfU.
DR eggNOG; KOG0751; Eukaryota.
DR HOGENOM; CLU_015166_3_3_1; -.
DR InParanoid; Q54S10; -.
DR OMA; KTRLQFQ; -.
DR PhylomeDB; Q54S10; -.
DR PRO; PR:Q54S10; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 1.50.40.10; -; 2.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..390
FT /note="Mitochondrial substrate carrier family protein U"
FT /id="PRO_0000385527"
FT TOPO_DOM 1..57
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250"
FT TRANSMEM 58..78
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 79..124
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250"
FT TRANSMEM 125..145
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 146..186
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250"
FT TRANSMEM 187..207
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 208..250
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250"
FT TRANSMEM 251..271
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 272..303
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250"
FT TRANSMEM 304..324
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 325..370
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250"
FT TRANSMEM 371..381
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 382..390
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250"
FT REPEAT 56..148
FT /note="Solcar 1"
FT REPEAT 188..280
FT /note="Solcar 2"
FT REPEAT 298..388
FT /note="Solcar 3"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 390 AA; 43989 MW; 50848BF752BDC4AC CRC64;
MNQKKQIKSD NLQQQQQQQQ QQQQQQQQQQ QQQQQQQQQK QHIKYLNSNF KDVEKNKILV
HLIAGSGSKL VESLVMFPLD TIKTRLQFQG DFSRGSIKNR YSGIVNAFKT TIRSEGILSL
YRGYIPHTLY VLPASAISFV CYEAIVQEAK KSKKFKNMMF DTSGIKAVKE TGEDLRNGGS
TSTSSGRFGV LLPIFVMTIA RITGSVLRTP FDVVKMRQQV SGSLVNEHVK KTNSTAFNSA
LKIIKTDGII GLFKYSYVSL LRDLPFTAIY FSTYEFSRNY QKHLINRGLK SGEKKKKLSS
INNLISGSLA GAFGTTLTIP IDVIKTNLQT QDLLPKEKRV FNGVISAFKY IIKNEGFKGL
TKGLSTRLIH IVPSAGLSFC AYEYIKKLLL
