MCFV_DICDI
ID MCFV_DICDI Reviewed; 527 AA.
AC Q551X6; Q1MVR0;
DT 13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 97.
DE RecName: Full=Mitochondrial substrate carrier family protein V;
GN Name=mcfV; ORFNames=DDB_G0276261;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [3]
RP REVIEW.
RX PubMed=17442478; DOI=10.1016/j.biochi.2007.03.004;
RA Satre M., Mattei S., Aubry L., Gaudet P., Pelosi L., Brandolin G.,
RA Klein G.;
RT "Mitochondrial carrier family: repertoire and peculiarities of the cellular
RT slime mould Dictyostelium discoideum.";
RL Biochimie 89:1058-1069(2007).
CC -!- FUNCTION: Mitochondrial solute carriers shuttle metabolites,
CC nucleotides, and cofactors through the mitochondrial inner membrane.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000014; EAL69430.1; -; Genomic_DNA.
DR RefSeq; XP_643352.1; XM_638260.1.
DR AlphaFoldDB; Q551X6; -.
DR SMR; Q551X6; -.
DR PaxDb; Q551X6; -.
DR EnsemblProtists; EAL69430; EAL69430; DDB_G0276261.
DR GeneID; 8620402; -.
DR KEGG; ddi:DDB_G0276261; -.
DR dictyBase; DDB_G0276261; mcfV.
DR eggNOG; KOG0752; Eukaryota.
DR HOGENOM; CLU_552649_0_0_1; -.
DR InParanoid; Q551X6; -.
DR OMA; VLRRRMM; -.
DR PhylomeDB; Q551X6; -.
DR Reactome; R-DDI-196783; Coenzyme A biosynthesis.
DR PRO; PR:Q551X6; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..527
FT /note="Mitochondrial substrate carrier family protein V"
FT /id="PRO_0000385528"
FT TOPO_DOM 1..132
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250"
FT TRANSMEM 133..153
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 154..187
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250"
FT TRANSMEM 188..208
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 209..258
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250"
FT TRANSMEM 259..279
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 280..324
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250"
FT TRANSMEM 325..345
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 346..435
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250"
FT TRANSMEM 436..456
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 457..487
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250"
FT TRANSMEM 488..508
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 509..527
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250"
FT REPEAT 130..220
FT /note="Solcar 1"
FT REPEAT 253..345
FT /note="Solcar 2"
FT REPEAT 430..519
FT /note="Solcar 3"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 527 AA; 57744 MW; 769AEC6F758ED52C CRC64;
MNSSDFKKSF KESTENNSNT YRPSKTLNTY KSLKNGNNIA NSLIIQLNNN VNNNLNKEKL
IKSNNNKLLN LNNNNKNNNN NNINNNNNLI SKNGILNNII KNENQNKILK GNNKNNSNSK
LDVSKKSISK ENVNYLVSGS IAGAISRSAT AGFERLTIIQ QVQGMSQNLS QGYVGCIAAM
KEMVKREGFK SIWKGNGANI VKVSPNSGIR FLTYEFCKKH FLDNSSNHPS SSSIENGIDG
NGVGCGSGSE MKMTVPQTMF SGAMAGLTST FFTYPLDVVR IRLSLQGSCS NDYAAHRYNG
ITHSFFKIHK DEGVKGLYKG LGTSIASIVP WVSISFATYE GFKIICKKMI LNYQISSSSL
STTTTTPSSI NNNNNNNNKN NNSFIYENEL GENGINLTNT SGCSTMASTM PSSLLINSVA
SDENELKKGV NMICDFVCGA LSGAVTMTVC YPLDVLRRRM MIQGIGGNKV LYKNGWDATK
KILSNEGLVA FYHGIIPAYF KVVPTVAISF AVYEICKDLG SNKYQQK
