ID   MCFY_DICDI              Reviewed;         436 AA.
AC   Q86HN8; Q555F5;
DT   13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Mitochondrial substrate carrier family protein Y;
GN   Name=mcfY; ORFNames=DDB_G0274501;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [3]
RP   REVIEW.
RX   PubMed=17442478; DOI=10.1016/j.biochi.2007.03.004;
RA   Satre M., Mattei S., Aubry L., Gaudet P., Pelosi L., Brandolin G.,
RA   Klein G.;
RT   "Mitochondrial carrier family: repertoire and peculiarities of the cellular
RT   slime mould Dictyostelium discoideum.";
RL   Biochimie 89:1058-1069(2007).
CC   -!- FUNCTION: Mitochondrial solute carriers shuttle metabolites,
CC       nucleotides, and cofactors through the mitochondrial inner membrane.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000012; EAL70143.1; -; Genomic_DNA.
DR   RefSeq; XP_644114.1; XM_639022.1.
DR   AlphaFoldDB; Q86HN8; -.
DR   SMR; Q86HN8; -.
DR   STRING; 44689.DDB0234132; -.
DR   PaxDb; Q86HN8; -.
DR   PRIDE; Q86HN8; -.
DR   EnsemblProtists; EAL70143; EAL70143; DDB_G0274501.
DR   GeneID; 8619544; -.
DR   KEGG; ddi:DDB_G0274501; -.
DR   dictyBase; DDB_G0274501; mcfY.
DR   eggNOG; KOG0762; Eukaryota.
DR   HOGENOM; CLU_015166_16_1_1; -.
DR   InParanoid; Q86HN8; -.
DR   OMA; TFDCLNQ; -.
DR   PhylomeDB; Q86HN8; -.
DR   Reactome; R-DDI-70635; Urea cycle.
DR   PRO; PR:Q86HN8; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0000064; F:L-ornithine transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:1990575; P:mitochondrial L-ornithine transmembrane transport; IBA:GO_Central.
DR   Gene3D; 1.50.40.10; -; 1.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   Pfam; PF00153; Mito_carr; 3.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Repeat; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..436
FT                   /note="Mitochondrial substrate carrier family protein Y"
FT                   /id="PRO_0000385531"
FT   TOPO_DOM        1..137
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        138..158
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        159..194
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        195..215
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        216..238
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        239..259
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        260..313
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        314..334
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        335..347
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        348..368
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        369..413
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        414..434
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        435..436
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000250"
FT   REPEAT          135..226
FT                   /note="Solcar 1"
FT   REPEAT          236..334
FT                   /note="Solcar 2"
FT   REPEAT          350..436
FT                   /note="Solcar 3"
FT   REGION          1..102
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   436 AA;  48164 MW;  5D04E659B9D1A1E9 CRC64;
     MENNNKNINT TNNSTTINTN NNNNPINKNN NNNNINNNNN NNINNINNIN NVNNNNNNNN
     NNNNNNNNNN NNNNNNNNNN NNNNNNINNN NNNINNNNIN KKNINNINKN KINNNNNNEI
     GEEKAVEGGF LAGLSRNVTR IIGSFSSGMA EESAGYPLDL IKTRIQLSQS GVSGGGGTNT
     SIIKIFKDVI KTEGVIGLFK GLSSPLILSA LVTAIQFGLF EDTLKYFRKH QYFKNHDTLS
     LLFSGSIAGF AQSFITCPVD LVKIQMQIQG IPSSQPNSNN NNNNNKAKGN SYFTKLIYRE
     KGLLGFYQGL SPTLFRDVPG LAIFFTTYET LKKQFGQPEL STQSPTEFIK SFIPIVLSGG
     SAGVFYHGLT HPFDIAKTLI QSDRSATKYK GTFDCLKQVY QNQGPKSLFK GFSAVAIKSF
     QSNAVGFLVY EMVINL