MCFZ_DICDI
ID MCFZ_DICDI Reviewed; 301 AA.
AC Q54B67;
DT 13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Mitochondrial substrate carrier family protein Z;
GN Name=mcfZ; Synonyms=mitA; ORFNames=DDB_G0293874;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP DEVELOPMENTAL STAGE.
RX PubMed=11553701; DOI=10.1091/mbc.12.9.2590;
RA Iranfar N., Fuller D., Sasik R., Hwa T., Laub M., Loomis W.F.;
RT "Expression patterns of cell-type-specific genes in Dictyostelium.";
RL Mol. Biol. Cell 12:2590-2600(2001).
RN [3]
RP DEVELOPMENTAL STAGE.
RX PubMed=12796308; DOI=10.1128/ec.2.3.627-637.2003;
RA Maeda M., Sakamoto H., Iranfar N., Fuller D., Maruo T., Ogihara S.,
RA Morio T., Urushihara H., Tanaka Y., Loomis W.F.;
RT "Changing patterns of gene expression in Dictyostelium prestalk cell
RT subtypes recognized by in situ hybridization with genes from microarray
RT analyses.";
RL Eukaryot. Cell 2:627-637(2003).
RN [4]
RP REVIEW.
RX PubMed=17442478; DOI=10.1016/j.biochi.2007.03.004;
RA Satre M., Mattei S., Aubry L., Gaudet P., Pelosi L., Brandolin G.,
RA Klein G.;
RT "Mitochondrial carrier family: repertoire and peculiarities of the cellular
RT slime mould Dictyostelium discoideum.";
RL Biochimie 89:1058-1069(2007).
CC -!- FUNCTION: Mitochondrial solute carriers shuttle metabolites,
CC nucleotides, and cofactors through the mitochondrial inner membrane.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- DEVELOPMENTAL STAGE: Present in vegetative cells but expression
CC decreases rapidly after the initiation of development. Accumulates also
CC in prestalk cells. {ECO:0000269|PubMed:11553701,
CC ECO:0000269|PubMed:12796308}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000223; EAL60508.1; -; Genomic_DNA.
DR RefSeq; XP_628921.1; XM_628919.1.
DR AlphaFoldDB; Q54B67; -.
DR SMR; Q54B67; -.
DR STRING; 44689.DDB0229992; -.
DR PaxDb; Q54B67; -.
DR EnsemblProtists; EAL60508; EAL60508; DDB_G0293874.
DR GeneID; 8629463; -.
DR KEGG; ddi:DDB_G0293874; -.
DR dictyBase; DDB_G0293874; mcfZ.
DR eggNOG; KOG0756; Eukaryota.
DR HOGENOM; CLU_015166_5_0_1; -.
DR InParanoid; Q54B67; -.
DR OMA; VRFLFFD; -.
DR PhylomeDB; Q54B67; -.
DR PRO; PR:Q54B67; -.
DR Proteomes; UP000002195; Chromosome 6.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0005469; F:succinate:fumarate antiporter activity; ISS:dictyBase.
DR GO; GO:0015741; P:fumarate transport; ISS:dictyBase.
DR GO; GO:0015744; P:succinate transport; ISS:dictyBase.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..301
FT /note="Mitochondrial substrate carrier family protein Z"
FT /id="PRO_0000385532"
FT TOPO_DOM 1..19
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250"
FT TRANSMEM 20..37
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 38..65
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250"
FT TRANSMEM 66..86
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 87..117
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250"
FT TRANSMEM 118..138
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 139..174
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250"
FT TRANSMEM 175..191
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 192..212
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250"
FT TRANSMEM 213..229
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 230..275
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250"
FT TRANSMEM 276..296
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 297..301
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250"
FT REPEAT 14..101
FT /note="Solcar 1"
FT REPEAT 116..200
FT /note="Solcar 2"
FT REPEAT 210..293
FT /note="Solcar 3"
SQ SEQUENCE 301 AA; 33268 MW; 57BC42A3C09EBA30 CRC64;
MTGKEENKQQ QHVNFPWKRL VAGAVAGTAD VWACHPLDRI KTQLQNNPGK SIVGTFGDIV
SKGKGFTGGV NALYEGILPM TAEAIFKVGI RYFAFSWFTE QYKTTVYKGE TLNKKQQFGA
NLLGGAFAGT IESFVVVIPC ELLKVRHMTQ EHNKSFGTVF RDVLREEGFQ GLYKGGSATL
LRQITNHMIR FPTFYAISDY LKGGDHSVHL PVWQNLSAGA IAGTASTLFN NPLDTIKTRM
QKQGQNQTTM QVVRGIYQET GVKGYWAGVI PRILRVAPGQ AITWAVVELV MGILEPSSKK
H
