ID   MCH1_ASHGO              Reviewed;         450 AA.
AC   Q752I1;
DT   25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Probable transporter MCH1;
GN   Name=MCH1; OrderedLocusNames=AFR595W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Probable transporter. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
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DR   EMBL; AE016819; AAS53966.1; -; Genomic_DNA.
DR   RefSeq; NP_986142.1; NM_212278.1.
DR   AlphaFoldDB; Q752I1; -.
DR   SMR; Q752I1; -.
DR   STRING; 33169.AAS53966; -.
DR   EnsemblFungi; AAS53966; AAS53966; AGOS_AFR595W.
DR   GeneID; 4622425; -.
DR   KEGG; ago:AGOS_AFR595W; -.
DR   eggNOG; ENOG502QTNE; Eukaryota.
DR   HOGENOM; CLU_012596_3_0_1; -.
DR   InParanoid; Q752I1; -.
DR   OMA; WRGPGGW; -.
DR   Proteomes; UP000000591; Chromosome VI.
DR   GO; GO:0000329; C:fungal-type vacuole membrane; IEA:EnsemblFungi.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport; Vacuole.
FT   CHAIN           1..450
FT                   /note="Probable transporter MCH1"
FT                   /id="PRO_0000084866"
FT   TRANSMEM        32..52
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        96..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        127..147
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        157..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        199..219
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        255..275
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        290..309
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        320..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        355..375
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        378..398
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        423..443
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   450 AA;  48936 MW;  B76679B4026B5D28 CRC64;
     MSLSSLEHKL TYHVRNWLHG SGFAWNTLHM SAFLVALCAC IPAGFISQIS LYSEPWREHL
     GYSVVEVNVL FSAVNLGGYI TPPLLGLLSD AHGPVMLSWL SFVGFVPTYA YAAWVFASGE
     PHFYASVLCF TLIGISTNAL YFSALFTASK LYPASKLCSI SLPATFYGMA SVLGSQLLKI
     PWFRNGLPYL DLSRVFRTLA VAYTLISFCM WFATSIVTML KVKAATLTFA GMQSPTEPLL
     PQDIRRRLRN FFHDPAAYFM ALVLLLSLGP MEMFLTNMGS LSSLLGQASV LPEFAIASTC
     SRFLSGLIID LCIHNGVSTM SVQWAVLLLG VVGQWIVVLA TRASDGPLLS LASALSGACY
     GGLFTVSPIL TLAVWGDAVF GTAYGSFMIT PAVGSILFGL TYAHIFDANC TPSGVLPVCI
     QHVFWSSTSA LAIALLFSVL MYLVFWRRKV