ID   MCH1_ASPFU              Reviewed;         619 AA.
AC   Q4WVT3;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Probable transporter mch1;
GN   Name=mch1; ORFNames=AFUA_5G13230;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: Probable transporter. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
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DR   EMBL; AAHF01000003; EAL91293.1; -; Genomic_DNA.
DR   RefSeq; XP_753331.1; XM_748238.1.
DR   AlphaFoldDB; Q4WVT3; -.
DR   STRING; 746128.CADAFUBP00005953; -.
DR   EnsemblFungi; EAL91293; EAL91293; AFUA_5G13230.
DR   GeneID; 3511658; -.
DR   KEGG; afm:AFUA_5G13230; -.
DR   VEuPathDB; FungiDB:Afu5g13230; -.
DR   eggNOG; ENOG502QTNE; Eukaryota.
DR   HOGENOM; CLU_012596_2_0_1; -.
DR   InParanoid; Q4WVT3; -.
DR   OMA; WRGPGGW; -.
DR   OrthoDB; 662984at2759; -.
DR   Proteomes; UP000002530; Chromosome 5.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport; Vacuole.
FT   CHAIN           1..619
FT                   /note="Probable transporter mch1"
FT                   /id="PRO_0000084867"
FT   TRANSMEM        88..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        120..140
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        147..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        184..204
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        219..239
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        261..281
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        377..397
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        428..448
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        480..500
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        515..535
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        541..561
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        589..609
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   619 AA;  67442 MW;  6718285543DB0022 CRC64;
     MAGPDQHYEP AIDKRDFDDH RPLLHDIDTG IDGTGDGRLR SDSRLSAFRN LDGGSDGLLN
     DVVDEIVERD RRKMAMEVMR VCSFAVGVIS CLGAGSITAF SLYGPLFLTR LHYSQLQVNA
     VSIAAEISMY LPVPLFGYLC DRYTPSPLAL LSGLVFGGGY LLAAFAYRSG PLPEAGGEGW
     PPWVMVVAFV AIGTATSCMY LAAVTTCAKN FGRGKHKGIM LAVPIAGFGL SGMWQSQVAT
     YLLCERREDG SRGDVDVFRY FLFLALFLFC LGVIGTFGLR IVDEEEDQYI DEAVEELERS
     GLLEESEFFR PRSEVQAAYG TFSDAADGDA PGPELSLTLS EEEREAARLE KEREEEERRK
     KNWLLNFETR LFLQDQTMWW LAVGFFLVTG PGEAYINNLG TIIQTLTPEL HPPNAPSPAG
     LPSTHVTIIA LTSTIARLLT GSLSDFFAPP ATHLFPANIE SGRRSSQSGP TAKRPTLSRL
     AFLLPSALLL SLGYLLLSSP LPLQHPGLSH VTTALIGLGY GSAFSLVPII ISVVWGVENF
     GTNWGIVAMV PAAGAAMWGV IYSRGYQDAT DGGNGSPDGQ CHGWRCYGFW AVGCTLSVWV
     AVVAWILAWR GWRRRGVVV