ID   MCH1_CANAL              Reviewed;         436 AA.
AC   Q59MJ2; A0A1D8PKX6; Q9P8Q3;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Probable transporter MCH1;
GN   Name=MCH1; OrderedLocusNames=CAALFM_C307850WA; ORFNames=CaO19.6180;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-264.
RX   PubMed=12702281; DOI=10.1111/j.1567-1364.2002.tb00100.x;
RA   Eschrich D., Koetter P., Entian K.-D.;
RT   "Gluconeogenesis in Candida albicans.";
RL   FEMS Yeast Res. 2:315-325(2002).
CC   -!- FUNCTION: Probable transporter. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
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DR   EMBL; CP017625; AOW28783.1; -; Genomic_DNA.
DR   EMBL; AF222906; AAF34694.1; -; Genomic_DNA.
DR   RefSeq; XP_710936.1; XM_705844.1.
DR   AlphaFoldDB; Q59MJ2; -.
DR   SMR; Q59MJ2; -.
DR   STRING; 237561.Q59MJ2; -.
DR   PRIDE; Q59MJ2; -.
DR   GeneID; 3647466; -.
DR   KEGG; cal:CAALFM_C307850WA; -.
DR   CGD; CAL0000193330; orf19.6180.
DR   VEuPathDB; FungiDB:C3_07850W_A; -.
DR   eggNOG; ENOG502QTNE; Eukaryota.
DR   HOGENOM; CLU_012596_3_0_1; -.
DR   InParanoid; Q59MJ2; -.
DR   OMA; WRGPGGW; -.
DR   OrthoDB; 662984at2759; -.
DR   Proteomes; UP000000559; Chromosome 3.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport; Vacuole.
FT   CHAIN           1..436
FT                   /note="Probable transporter MCH1"
FT                   /id="PRO_0000084868"
FT   TRANSMEM        27..47
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        66..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        93..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        119..139
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        155..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        188..208
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        249..269
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        295..312
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        325..345
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        347..367
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        373..393
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        410..430
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        278
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   436 AA;  47815 MW;  436EE9DFB8A71994 CRC64;
     MHKHLHHVSH TIKSYLSTLI ALENLKVVAF LISLLSCLVA GSILLFTLYT SSFHEVLGLS
     YLQINMISSL SALGMYFCLP VLGYLADSYG PALLSLFSIW FFCPSYFVNS YLVSTQSGSV
     IGFCVCFCFI GLATSSLYFS SLITCARICP DHKGLAISLP ITCYGLSALL GAQILKLPYF
     HRHDVLDLEV VFSFFAWLYL VVGIASFVSS SIVIVESELL FGVTPDEETA LLELTPTRSL
     EPPNHRQRFV SFVKDPSAWI LLVSLILNIG PMESYQNNLS SILKHTNGAD LPNQVSIMAA
     SSTGARLLLG VLSDYSSKYV CRVWLLVVVI VVGVAGQMSE TSAILNGVSY GGMFTIYPTI
     VASIWGIDIM GSTWGSFMVA PALGSVIFSM FYGRNADSCS DCLSHYFYTT AGAMIVSCIF
     VLLAWKIWYA RGFTRF