MCH1_ONCKE
ID MCH1_ONCKE Reviewed; 132 AA.
AC P19713; P01208;
DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1991, sequence version 1.
DT 25-MAY-2022, entry version 62.
DE RecName: Full=Pro-MCH 1;
DE Contains:
DE RecName: Full=Neuropeptide-glutamic acid-valine;
DE AltName: Full=Neuropeptide E-V;
DE Short=NEV;
DE Contains:
DE RecName: Full=Melanin-concentrating hormone;
DE Short=MCH;
DE Flags: Precursor;
GN Name=mch1;
OS Oncorhynchus keta (Chum salmon) (Salmo keta).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8018;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2792771; DOI=10.1016/0378-1119(89)90251-5;
RA Takayama Y., Wada C., Kawauchi H., Ono M.;
RT "Structures of two genes coding for melanin-concentrating hormone of chum
RT salmon.";
RL Gene 80:65-73(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2465207; DOI=10.1016/0378-1119(88)90060-1;
RA Ono M., Wada C., Oikawa I., Kawazoe I., Kawauchi H.;
RT "Structures of two kinds of mRNA encoding the chum salmon melanin-
RT concentrating hormone.";
RL Gene 71:433-438(1988).
RN [3]
RP PROTEIN SEQUENCE OF 116-132.
RX PubMed=6621686; DOI=10.1038/305321a0;
RA Kawauchi H., Kawazoe I., Tsubokawa M., Kishida M., Baker B.I.;
RT "Characterization of melanin-concentrating hormone in chum salmon
RT pituitaries.";
RL Nature 305:321-323(1983).
CC -!- FUNCTION: Plays a role in skin pigmentation by antagonizing the action
CC of melanotropin alpha. Induces melanin concentration within the
CC melanophores. May participate in the control of the hypothalamo-
CC pituitary adrenal gland axis by inhibiting the release of ACTH.
CC -!- TISSUE SPECIFICITY: Pituitary gland. Produced in neurons of lateral
CC basal hypothalamus which project both to the brain and to the neural
CC lobe of the pituitary gland from where MCH is released.
CC -!- SIMILARITY: Belongs to the melanin-concentrating hormone family.
CC {ECO:0000305}.
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DR EMBL; M27872; AAA49418.1; -; Genomic_DNA.
DR EMBL; M23573; AAA49420.1; -; mRNA.
DR PIR; JS0282; MTON1K.
DR AlphaFoldDB; P19713; -.
DR BMRB; P19713; -.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0030354; F:melanin-concentrating hormone activity; IEA:InterPro.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR InterPro; IPR005456; Prepro-melanin_conc_hormone.
DR PANTHER; PTHR12091; PTHR12091; 1.
DR Pfam; PF05824; Pro-MCH; 1.
DR PRINTS; PR01641; PROMCHFAMILY.
PE 1: Evidence at protein level;
KW Cleavage on pair of basic residues; Direct protein sequencing;
KW Disulfide bond; Hormone; Neuropeptide; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..132
FT /note="Pro-MCH 1"
FT /id="PRO_0000019120"
FT PEPTIDE 101..113
FT /note="Neuropeptide-glutamic acid-valine"
FT /evidence="ECO:0000255"
FT /id="PRO_0000019121"
FT PEPTIDE 116..132
FT /note="Melanin-concentrating hormone"
FT /evidence="ECO:0000269|PubMed:6621686"
FT /id="PRO_0000019122"
FT DISULFID 120..129
FT /evidence="ECO:0000269|PubMed:6621686"
FT CONFLICT 4
FT /note="Y -> S (in Ref. 2; AAA49420)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 132 AA; 14682 MW; CE9CF95292498738 CRC64;
MRHYVLSISF AVALFLECYT PSTAISIGKM DDVALEQDTL DSLLSVEVSE NSPDSVRGRS
SKIVLLADSG LWMNLNRGLP FYKLRAAAAG PDRALTLDRR EAGQDLSPSI SIVRRDTMRC
MVGRVYRPCW EV
