ID   MCH1_ONCKI              Reviewed;         132 AA.
AC   P56943;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 52.
DE   RecName: Full=Pro-MCH 1;
DE   Contains:
DE     RecName: Full=Neuropeptide-glutamic acid-valine;
DE     AltName: Full=Neuropeptide E-V;
DE              Short=NEV;
DE   Contains:
DE     RecName: Full=Melanin-concentrating hormone;
DE              Short=MCH;
DE   Flags: Precursor;
GN   Name=mch1;
OS   Oncorhynchus kisutch (Coho salmon) (Salmo kisutch).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=8019;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RA   Nahon J.-L., Presse F., Schoepfer R., Vale W.;
RT   "Identification of a single melanin-concentrating hormone messenger
RT   ribonucleic acid in Coho salmon: structural relatedness with riobonucleic
RT   acid.";
RL   J. Neuroendocrinol. 3:173-183(1991).
CC   -!- FUNCTION: Plays a role in skin pigmentation by antagonizing the action
CC       of melanotropin alpha. Induces melanin concentration within the
CC       melanophores. May participate in the control of the hypothalamo-
CC       pituitary adrenal gland axis by inhibiting the release of ACTH.
CC   -!- TISSUE SPECIFICITY: Pituitary gland. Produced in neurons of lateral
CC       basal hypothalamus which project both to the brain and to the neural
CC       lobe of the pituitary gland from where MCH is released.
CC   -!- SIMILARITY: Belongs to the MCH family. {ECO:0000305}.
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DR   AlphaFoldDB; P56943; -.
DR   BMRB; P56943; -.
DR   Proteomes; UP000694557; Unplaced.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0030354; F:melanin-concentrating hormone activity; IEA:InterPro.
DR   GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR005456; Prepro-melanin_conc_hormone.
DR   PANTHER; PTHR12091; PTHR12091; 1.
DR   Pfam; PF05824; Pro-MCH; 1.
DR   PRINTS; PR01641; PROMCHFAMILY.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond; Hormone; Neuropeptide;
KW   Reference proteome; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..132
FT                   /note="Pro-MCH 1"
FT                   /id="PRO_0000019123"
FT   PEPTIDE         101..113
FT                   /note="Neuropeptide-glutamic acid-valine"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000019124"
FT   PEPTIDE         116..132
FT                   /note="Melanin-concentrating hormone"
FT                   /id="PRO_0000019125"
FT   DISULFID        120..129
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   132 AA;  14668 MW;  8B9348336EBB1AA8 CRC64;
     MRDSVLSVIF ALALFLECYT PSMAIPMGKM EDTALEQDTL DSLLNESVAD KNPDSVRSGS
     SKIIVLADSG MWKNLNRGLP LYKLKAAAAG LDRALTLDRR EADQDLSPSI SIVRRDTMRC
     MVGRVYRPCW EV