ID   MCH1_ONCTS              Reviewed;         132 AA.
AC   P17640;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Pro-MCH 1;
DE   Contains:
DE     RecName: Full=Neuropeptide-glutamic acid-valine;
DE     AltName: Full=Neuropeptide E-V;
DE              Short=NEV;
DE   Contains:
DE     RecName: Full=Melanin-concentrating hormone;
DE              Short=MCH;
DE   Flags: Precursor;
GN   Name=mch1;
OS   Oncorhynchus tshawytscha (Chinook salmon) (Salmo tshawytscha).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=74940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2471200; DOI=10.1073/pnas.86.11.4292;
RA   Minth C.A., Qiu H., Akil H., Watson S.J., Dixon J.E.;
RT   "Two precursors of melanin-concentrating hormone: DNA sequence analysis and
RT   in situ immunochemical localization.";
RL   Proc. Natl. Acad. Sci. U.S.A. 86:4292-4296(1989).
CC   -!- FUNCTION: Plays a role in skin pigmentation by antagonizing the action
CC       of melanotropin alpha. Induces melanin concentration within the
CC       melanophores. May participate in the control of the hypothalamo-
CC       pituitary adrenal gland axis by inhibiting the release of ACTH.
CC   -!- TISSUE SPECIFICITY: Pituitary gland. Produced in neurons of lateral
CC       basal hypothalamus which project both to the brain and to the neural
CC       lobe of the pituitary gland from where MCH is released.
CC   -!- SIMILARITY: Belongs to the melanin-concentrating hormone family.
CC       {ECO:0000305}.
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DR   EMBL; M25755; AAA49423.1; -; mRNA.
DR   PIR; B32910; B32910.
DR   AlphaFoldDB; P17640; -.
DR   BMRB; P17640; -.
DR   Proteomes; UP000694402; Unplaced.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0030354; F:melanin-concentrating hormone activity; IEA:InterPro.
DR   GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR005456; Prepro-melanin_conc_hormone.
DR   PANTHER; PTHR12091; PTHR12091; 1.
DR   Pfam; PF05824; Pro-MCH; 1.
DR   PRINTS; PR01641; PROMCHFAMILY.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond; Hormone; Neuropeptide;
KW   Reference proteome; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..132
FT                   /note="Pro-MCH 1"
FT                   /id="PRO_0000019129"
FT   PEPTIDE         101..113
FT                   /note="Neuropeptide-glutamic acid-valine"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000019130"
FT   PEPTIDE         116..132
FT                   /note="Melanin-concentrating hormone"
FT                   /id="PRO_0000019131"
FT   DISULFID        120..129
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   132 AA;  14657 MW;  F2065B83AFAB46E5 CRC64;
     MRHSVLSISF AVALFLECYT PSTAIPIGKM DDVALEQDTL DSLLRVEVSE NSPDSVRGRS
     SKIVLLADSG LWMNLNRGLP FYKLRAAAAG PDRALTLDRQ EAGQDLSPSI SIVRRDTMRC
     MVGRVYRPCW EV