ID   MCH1_WICAO              Reviewed;         489 AA.
AC   Q96TW9;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Probable transporter MCH1;
GN   Name=MCH1; ORFNames=PaYDL054c;
OS   Wickerhamomyces anomalus (Yeast) (Hansenula anomala).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Phaffomycetaceae; Wickerhamomyces.
OX   NCBI_TaxID=4927;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 36904 / CBS 1982 / NCYC 435 / NRRL Y-2153-4;
RX   PubMed=11561286; DOI=10.1002/yea.766;
RA   Ruiz T., Sanchez M., de la Rosa J.M., Rodriguez L., Dominguez A.;
RT   "The sequence of a 15 769 bp segment of Pichia anomala identifies the SEC61
RT   and FBP1 genes and five new open reading frames.";
RL   Yeast 18:1187-1195(2001).
CC   -!- FUNCTION: Probable transporter. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
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DR   EMBL; AJ306295; CAC69140.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q96TW9; -.
DR   SMR; Q96TW9; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   3: Inferred from homology;
KW   Membrane; Transmembrane; Transmembrane helix; Transport; Vacuole.
FT   CHAIN           1..489
FT                   /note="Probable transporter MCH1"
FT                   /id="PRO_0000084873"
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        94..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        124..144
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        156..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        196..216
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        262..282
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        302..324
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        335..355
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        359..379
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        403..423
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        463..483
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   489 AA;  54230 MW;  7B672337B7B18622 CRC64;
     MALSSIETAL TKHIRSLLQT HFSTKSLKRL ACSISLISCL CAGSVLLFAL FTPVLQHQLH
     YTQFQINIIG SFTSIGMYLP LPVLGYLADC HGPVLLSVIS VLFFSPGYTL AATVVQNDWS
     FWYLAISFGL IGCATSALYF TALLTCAKIY PKSKGLTISA PVTCYGLSSL IGSRVLKLSC
     LQKNGDLDLY RCFKLFSFLY FFLGLFDWVS ASVVSIERDV LLRKHEDGEN TPLLTDPNQE
     HENNDDLVPN HKSKFLKFIK DISTYVLLFS LLLSIGPSEM YITNMGSLVK AITPNSLISD
     QVAIHAVFST LSRLSLGALS DFLVTNYQIS RSWLLLSIIV LGFFTQIFIA TSTFVKDQYY
     IISALSGFSY GGLFTLYPTV IFSIWGPEIF GSAWGSFMIA PAIGSTTFGM VFGLVYDSAC
     GVFAESTTGN CVSLVFLDQL LSIRLQCSTV THCMEGDLDQ KRSLIIINHL HYIKYIYLLI
     LRIHLSRET