ID   MCH1_YARLI              Reviewed;         486 AA.
AC   Q6CGU8;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Probable transporter MCH1;
GN   Name=MCH1; OrderedLocusNames=YALI0A16060g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Probable transporter. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
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DR   EMBL; CR382127; CAG84045.1; -; Genomic_DNA.
DR   RefSeq; XP_500114.1; XM_500114.1.
DR   AlphaFoldDB; Q6CGU8; -.
DR   SMR; Q6CGU8; -.
DR   STRING; 4952.CAG84045; -.
DR   EnsemblFungi; CAG84045; CAG84045; YALI0_A16060g.
DR   GeneID; 2906009; -.
DR   KEGG; yli:YALI0A16060g; -.
DR   VEuPathDB; FungiDB:YALI0_A16060g; -.
DR   HOGENOM; CLU_012596_2_0_1; -.
DR   InParanoid; Q6CGU8; -.
DR   OMA; WRGPGGW; -.
DR   Proteomes; UP000001300; Chromosome A.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport; Vacuole.
FT   CHAIN           1..486
FT                   /note="Probable transporter MCH1"
FT                   /id="PRO_0000084876"
FT   TRANSMEM        31..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        174..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        211..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        268..288
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        312..333
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        349..369
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        377..397
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        409..429
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        457..477
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   486 AA;  52293 MW;  E3EE54C4AE2B785B CRC64;
     MVDERTPLKA VTTREDAPTA VMRPKPVGKS IFALSILGTL SAASISLFSM YGQTLQHKLG
     FTQVQVNSVS ISSLLGMYLL MPVIGYLGDT YGSNYLALFS WITFPASYSI ASGIFSTAAD
     WHRETGEALP RAAPEMALCF FFIGASTSCM YYASLKASAH SMSVYFAEDG KLQTYTPGYA
     IWGPVAAFGL SSLWQSQLLR AVFITGKNVN VAGIFLFFAG LYAVICGIIF FSCRTAESMA
     SELRKKAEAS TDCNCDGPGH EGATLKEFFT DKTAWLFLLC FVFIGGPFEM FQNNMGAILD
     TVTVENADSP SFSTHVSLFA TFSTVSRLVV GFSSEAMESH VSRPVLLSVI ALVAACIHLM
     VPSGIFTVFD NAKYFSVVTI VNGFSYGSSF TLVPTIVTKV WGIANLGTIW GSFILALAVG
     SLGYGLLFAK VYDAASEVGV GSMSQVCSGV HCYGLTFVIT GTGLAFAAAA VFFIWVFMWK
     KRGIHM