ID   MCH2_ONCKE              Reviewed;         132 AA.
AC   P69155; P01208; P19714;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Pro-MCH 2;
DE   Contains:
DE     RecName: Full=Neuropeptide-glutamic acid-valine;
DE     AltName: Full=Neuropeptide E-V;
DE              Short=NEV;
DE   Contains:
DE     RecName: Full=Melanin-concentrating hormone;
DE              Short=MCH;
DE   Flags: Precursor;
GN   Name=mch2;
OS   Oncorhynchus keta (Chum salmon) (Salmo keta).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=8018;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=2471156; DOI=10.1093/nar/17.9.3598;
RA   Nahon J.-L., Schoepfer R., Vale W.;
RT   "cDNA sequence of salmon melanin-concentrating hormone exhibits
RT   similarities with 7SL RNA.";
RL   Nucleic Acids Res. 17:3598-3598(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2792771; DOI=10.1016/0378-1119(89)90251-5;
RA   Takayama Y., Wada C., Kawauchi H., Ono M.;
RT   "Structures of two genes coding for melanin-concentrating hormone of chum
RT   salmon.";
RL   Gene 80:65-73(1989).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2465207; DOI=10.1016/0378-1119(88)90060-1;
RA   Ono M., Wada C., Oikawa I., Kawazoe I., Kawauchi H.;
RT   "Structures of two kinds of mRNA encoding the chum salmon melanin-
RT   concentrating hormone.";
RL   Gene 71:433-438(1988).
RN   [4]
RP   PROTEIN SEQUENCE OF 116-132.
RX   PubMed=6621686; DOI=10.1038/305321a0;
RA   Kawauchi H., Kawazoe I., Tsubokawa M., Kishida M., Baker B.I.;
RT   "Characterization of melanin-concentrating hormone in chum salmon
RT   pituitaries.";
RL   Nature 305:321-323(1983).
CC   -!- FUNCTION: Plays a role in skin pigmentation by antagonizing the action
CC       of melanotropin alpha. Induces melanin concentration within the
CC       melanophores. May participate in the control of the hypothalamo-
CC       pituitary adrenal gland axis by inhibiting the release of ACTH.
CC   -!- TISSUE SPECIFICITY: Pituitary gland. Produced in neurons of lateral
CC       basal hypothalamus which project both to the brain and to the neural
CC       lobe of the pituitary gland from where MCH is released.
CC   -!- SIMILARITY: Belongs to the melanin-concentrating hormone family.
CC       {ECO:0000305}.
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DR   EMBL; X13685; CAA31978.1; -; mRNA.
DR   EMBL; M23574; AAA49421.1; -; mRNA.
DR   EMBL; M27871; AAA49419.1; -; Genomic_DNA.
DR   PIR; JS0283; MTON2K.
DR   AlphaFoldDB; P69155; -.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0030354; F:melanin-concentrating hormone activity; IEA:InterPro.
DR   GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR005456; Prepro-melanin_conc_hormone.
DR   PANTHER; PTHR12091; PTHR12091; 1.
DR   Pfam; PF05824; Pro-MCH; 1.
DR   PRINTS; PR01641; PROMCHFAMILY.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Direct protein sequencing;
KW   Disulfide bond; Hormone; Neuropeptide; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..132
FT                   /note="Pro-MCH 2"
FT                   /id="PRO_0000019132"
FT   PEPTIDE         101..113
FT                   /note="Neuropeptide-glutamic acid-valine"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000019133"
FT   PEPTIDE         116..132
FT                   /note="Melanin-concentrating hormone"
FT                   /id="PRO_0000019134"
FT   DISULFID        120..129
FT   CONFLICT        107..108
FT                   /note="SP -> NS (in Ref. 2; AAA49419)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        107
FT                   /note="S -> N (in Ref. 3; AAA49421)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   132 AA;  14710 MW;  AAE55F456EA26FE4 CRC64;
     MRDSVLSVIF ALALFLECYT PSMAIPMGKM EDTALEQDTL DSLLNEEVAD KNPDSVRSGS
     SKIIVLADSG MWKNLNRGLP LYKLKAAAAG LDRALTLDRR EADQDLSPSI SIVRRDTMRC
     MVGRVYRPCW EV