ID   MCHB_ECOL6              Reviewed;          75 AA.
AC   P62531; Q9RM53;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Microcin H47;
DE            Short=MccH47;
DE   Flags: Precursor;
GN   Name=mchB; OrderedLocusNames=c1227;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- FUNCTION: Bactericidal antibiotic. Active on bacteria phylogenetically
CC       related to the producing strain (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Host cell membrane
CC       {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
CC       Note=Probably through the MchEF ABC transporter system. {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAN79685.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE014075; AAN79685.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_001375214.1; NC_004431.1.
DR   AlphaFoldDB; P62531; -.
DR   EnsemblBacteria; AAN79685; AAN79685; c1227.
DR   KEGG; ecc:c1227; -.
DR   HOGENOM; CLU_182906_0_0_6; -.
DR   OMA; PANQIGA; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Bacteriocin; Host cell membrane; Host membrane;
KW   Membrane; Secreted; Transmembrane; Transmembrane helix.
FT   PROPEP          1..15
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000021658"
FT   CHAIN           16..75
FT                   /note="Microcin H47"
FT                   /id="PRO_0000021659"
FT   TRANSMEM        30..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   75 AA;  6600 MW;  1AD5EE9F1B58123C CRC64;
     MREITESQLR YISGAGGAPA TSANAAGAAA IVGALAGIPG GPLGVVVGAV SAGLTTAIGS
     TVGSGSASSS AGGGS