ID   MCHL1_HUMAN             Reviewed;          86 AA.
AC   Q16048; Q9BQ10;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 2.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=Putative pro-MCH-like protein 1;
DE   AltName: Full=Pro-MCH variant;
DE   AltName: Full=Pro-melanin-concentrating hormone-like protein 1;
GN   Name=PMCHL1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC   TISSUE=Testis;
RX   PubMed=11181993; DOI=10.1126/science.1057284;
RA   Courseaux A., Nahon J.-L.;
RT   "Birth of two chimeric genes in the Hominidae lineage.";
RL   Science 291:1293-1297(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 9-86.
RC   TISSUE=Brain;
RX   PubMed=8326825; DOI=10.1016/0169-328x(93)90093-5;
RA   Breton C., Schorpp M., Nahon J.-L.;
RT   "Isolation and characterization of the human melanin-concentrating hormone
RT   gene and a variant gene.";
RL   Brain Res. Mol. Brain Res. 18:297-310(1993).
RN   [3]
RP   TISSUE SPECIFICITY.
RX   PubMed=9729295; DOI=10.1016/s0006-8993(98)00626-x;
RA   Miller C.L., Burmeister M., Thompson R.C.;
RT   "Antisense expression of the human pro-melanin-concentrating hormone
RT   genes.";
RL   Brain Res. 803:86-94(1998).
RN   [4]
RP   TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX   PubMed=11070051; DOI=10.1093/oxfordjournals.molbev.a026262;
RA   Viale A., Courseaux A., Presse F., Ortola C., Breton C., Jordan D.,
RA   Nahon J.-L.;
RT   "Structure and expression of the variant melanin-concentrating hormone
RT   genes: only PMCHL1 is transcribed in the developing human brain and encodes
RT   a putative protein.";
RL   Mol. Biol. Evol. 17:1626-1640(2000).
CC   -!- TISSUE SPECIFICITY: Expressed in testis and brain.
CC       {ECO:0000269|PubMed:11070051, ECO:0000269|PubMed:9729295}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in developing brain, found in fetal
CC       newborn and adult brain. {ECO:0000269|PubMed:11070051}.
CC   -!- SIMILARITY: Belongs to the melanin-concentrating hormone family.
CC       {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene. PubMed:9729295 reported
CC       that PMCHL1 mRNA may not be used as template for translation as only
CC       antisense PMCHL1 transcripts are present in brain. {ECO:0000305}.
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DR   EMBL; AY008411; AAK31295.1; -; mRNA.
DR   EMBL; AY028318; AAK31289.1; -; Genomic_DNA.
DR   EMBL; S64288; AAB27494.1; -; Genomic_DNA.
DR   PIR; I52634; I52634.
DR   AlphaFoldDB; Q16048; -.
DR   SMR; Q16048; -.
DR   BioMuta; HGNC:9110; -.
DR   DMDM; 59799837; -.
DR   PRIDE; Q16048; -.
DR   GeneCards; PMCHL1; -.
DR   HGNC; HGNC:9110; PMCHL1.
DR   MIM; 176793; gene.
DR   neXtProt; NX_Q16048; -.
DR   InParanoid; Q16048; -.
DR   PhylomeDB; Q16048; -.
DR   PathwayCommons; Q16048; -.
DR   Pharos; Q16048; Tdark.
DR   PRO; PR:Q16048; -.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; Q16048; protein.
DR   GO; GO:0005576; C:extracellular region; NAS:UniProtKB.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0030354; F:melanin-concentrating hormone activity; IEA:InterPro.
DR   GO; GO:0031777; F:type 1 melanin-concentrating hormone receptor binding; IBA:GO_Central.
DR   GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
DR   InterPro; IPR005456; Prepro-melanin_conc_hormone.
DR   PANTHER; PTHR12091; PTHR12091; 1.
DR   Pfam; PF05824; Pro-MCH; 1.
DR   PRINTS; PR01641; PROMCHFAMILY.
PE   5: Uncertain;
KW   Reference proteome.
FT   CHAIN           1..86
FT                   /note="Putative pro-MCH-like protein 1"
FT                   /id="PRO_0000158268"
FT   REGION          31..49
FT                   /note="NGE-like"
FT   REGION          38..62
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          52..64
FT                   /note="NEI-like"
FT   REGION          68..86
FT                   /note="Melanin-concentrating hormone-like"
FT   COMPBIAS        44..62
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   86 AA;  9715 MW;  BC5EC470EDA8F7F3 CRC64;
     MLSQKPKKKH NFLNHGLSLN LVIKPYLALE GSVAFPAENG VQDTESTQEK RETGDEENSA
     KFPVGRRDFD TLSCMLGRVY QSCWQV