ID   MCHL2_HUMAN             Reviewed;          86 AA.
AC   Q9BQD1;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Putative pro-MCH-like protein 2;
DE   AltName: Full=Pro-melanin-concentrating hormone-like protein 2;
GN   Name=PMCHL2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Testis;
RX   PubMed=11181993; DOI=10.1126/science.1057284;
RA   Courseaux A., Nahon J.-L.;
RT   "Birth of two chimeric genes in the Hominidae lineage.";
RL   Science 291:1293-1297(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8188237; DOI=10.1006/geno.1994.1008;
RA   Pedeutour F., Szpirer C., Nahon J.-L.;
RT   "Assignment of the human pro-melanin-concentrating hormone gene (PMCH) to
RT   chromosome 12q23-q24 and two variant genes (PMCHL1 and PMCHL2) to
RT   chromosome 5p14 and 5q12-q13.";
RL   Genomics 19:31-37(1994).
RN   [3]
RP   DEVELOPMENTAL STAGE.
RX   PubMed=11070051; DOI=10.1093/oxfordjournals.molbev.a026262;
RA   Viale A., Courseaux A., Presse F., Ortola C., Breton C., Jordan D.,
RA   Nahon J.-L.;
RT   "Structure and expression of the variant melanin-concentrating hormone
RT   genes: only PMCHL1 is transcribed in the developing human brain and encodes
RT   a putative protein.";
RL   Mol. Biol. Evol. 17:1626-1640(2000).
CC   -!- TISSUE SPECIFICITY: Expressed in testis but not in brain.
CC   -!- DEVELOPMENTAL STAGE: Not expressed during brain development.
CC       {ECO:0000269|PubMed:11070051}.
CC   -!- SIMILARITY: Belongs to the melanin-concentrating hormone family.
CC       {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR   EMBL; AY008413; AAK31297.1; -; mRNA.
DR   EMBL; AY008412; AAK31296.1; -; mRNA.
DR   EMBL; AY028320; AAK31290.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9BQD1; -.
DR   BioMuta; HGNC:9111; -.
DR   DMDM; 71153828; -.
DR   PRIDE; Q9BQD1; -.
DR   GeneCards; PMCHL2; -.
DR   HGNC; HGNC:9111; PMCHL2.
DR   MIM; 176794; gene.
DR   neXtProt; NX_Q9BQD1; -.
DR   InParanoid; Q9BQD1; -.
DR   PhylomeDB; Q9BQD1; -.
DR   PathwayCommons; Q9BQD1; -.
DR   Pharos; Q9BQD1; Tdark.
DR   PRO; PR:Q9BQD1; -.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; Q9BQD1; protein.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0030354; F:melanin-concentrating hormone activity; IEA:InterPro.
DR   GO; GO:0031777; F:type 1 melanin-concentrating hormone receptor binding; IBA:GO_Central.
DR   GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
DR   InterPro; IPR005456; Prepro-melanin_conc_hormone.
DR   PANTHER; PTHR12091; PTHR12091; 1.
DR   Pfam; PF05824; Pro-MCH; 1.
DR   PRINTS; PR01641; PROMCHFAMILY.
PE   5: Uncertain;
KW   Reference proteome.
FT   CHAIN           1..86
FT                   /note="Putative pro-MCH-like protein 2"
FT                   /id="PRO_0000158272"
FT   REGION          31..49
FT                   /note="NGE-like"
FT   REGION          40..60
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          52..64
FT                   /note="NEI-like"
FT   REGION          68..86
FT                   /note="Melanin-concentrating hormone-like"
FT   COMPBIAS        44..60
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   86 AA;  9856 MW;  1C8D69B786B47471 CRC64;
     MLSQKTKKKH NFLNHGLSLN LVIKPYLALE GSVAFPAENG VQDTESTLEK RETGDEENSA
     KFPIGRRDFD TLRCMLGRVY QRCWQV