MCHR2_HUMAN
ID MCHR2_HUMAN Reviewed; 340 AA.
AC Q969V1; B3KVW4; E1P5D7; Q5VTV7; Q6Q377; Q9BXA8;
DT 15-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Melanin-concentrating hormone receptor 2;
DE Short=MCH receptor 2;
DE Short=MCH-R2;
DE Short=MCHR-2;
DE AltName: Full=G-protein coupled receptor 145;
DE AltName: Full=GPRv17;
DE AltName: Full=MCH-2R;
DE Short=MCH2;
DE Short=MCH2R;
GN Name=MCHR2; Synonyms=GPR145, SLT;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11355873; DOI=10.1006/bbrc.2001.4893;
RA Mori M., Harada M., Terao Y., Sugo T., Watanabe T., Shimomura Y., Abe M.,
RA Shintani Y., Onda H., Nishimura O., Fujino M.;
RT "Cloning of a novel G protein-coupled receptor, SLT, a subtype of the
RT melanin-concentrating hormone receptor.";
RL Biochem. Biophys. Res. Commun. 283:1013-1018(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Fetal brain;
RX PubMed=11404457; DOI=10.1073/pnas.121170598;
RA Sailer A.W., Sano H., Zeng Z., McDonald T.P., Pan J., Pong S.-S.,
RA Feighner S.D., Tan C.P., Fukami T., Iwaasa H., Hreniuk D.L., Morin N.R.,
RA Sadowski S.J., Ito M., Ito M., Bansal A., Ky B., Figueroa D.J., Jiang Q.,
RA Austin C.P., MacNeil D.J., Ishihara A., Ihara M., Kanatani A.,
RA Van der Ploeg L.H.T., Howard A.D., Liu Q.;
RT "Identification and characterization of a second melanin-concentrating
RT hormone receptor, MCH-2R.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:7564-7569(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11459838; DOI=10.1074/jbc.m102601200;
RA Wang S., Behan J., O'Neill K., Weig B., Fried S., Laz T., Bayne M.,
RA Gustafson E., Hawes B.E.;
RT "Identification and pharmacological characterization of a novel human
RT melanin-concentrating hormone receptor, MCH-R2.";
RL J. Biol. Chem. 276:34664-34670(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11274220; DOI=10.1074/jbc.m102068200;
RA Hill J., Duckworth M., Murdock P., Rennie G., Sabido-David C., Ames R.S.,
RA Szekeres P., Wilson S., Bergsma D.J., Gloger I.S., Levy D.S.,
RA Chambers J.K., Muir A.I.;
RT "Molecular cloning and functional characterization of MCH2, a novel human
RT MCH receptor.";
RL J. Biol. Chem. 276:20125-20129(2001).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Kurama T., Matsumoto S., Takasaki J., Terai K., Matsumoto M., Kamohara M.,
RA Saito T., Soga T., Saito Y., Oda T., Masuho Y., Furuichi K.;
RT "Molecular characterization of a novel melanin-concentrating hormone
RT receptor: evidence of its expression in lateral hypothalamus.";
RL Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RA King M.M., Aronstam R.S., Sharma S.V.;
RT "cDNA clones of human proteins involved in signal transduction sequenced by
RT the Guthrie cDNA resource center (www.cdna.org).";
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [9]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [10]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [11]
RP VARIANTS LYS-63 AND GLN-152, AND CHARACTERIZATION OF VARIANTS LYS-63 AND
RP GLN-152.
RX PubMed=15340116; DOI=10.1038/oby.2004.167;
RA Hawes B.E., Green B., O'Neill K., Fried S., Arreaza M.G., Qiu P.,
RA Simon J.S.;
RT "Identification and characterization of single-nucleotide polymorphisms in
RT MCH-R1 and MCH-R2.";
RL Obes. Res. 12:1327-1334(2004).
CC -!- FUNCTION: Receptor for melanin-concentrating hormone, coupled to G
CC proteins that activate phosphoinositide hydrolysis.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Specifically expressed in the brain, with highest
CC levels in cerebral cortex, hippocampus and amygdala. No expression
CC detected in the cerebellum, thalamus or hypothalamus.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AB060151; BAB55677.1; -; mRNA.
DR EMBL; AY029596; AAK38157.1; -; mRNA.
DR EMBL; AF399937; AAL05528.1; -; mRNA.
DR EMBL; AF347063; AAK32193.1; -; mRNA.
DR EMBL; AB058849; BAB87842.1; -; mRNA.
DR EMBL; AY562946; AAS72374.1; -; mRNA.
DR EMBL; AK123634; BAG53926.1; -; mRNA.
DR EMBL; AL590725; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471051; EAW48460.1; -; Genomic_DNA.
DR EMBL; BC095515; AAH95515.1; -; mRNA.
DR CCDS; CCDS5044.1; -.
DR PIR; JC7695; JC7695.
DR RefSeq; NP_001035269.1; NM_001040179.1.
DR RefSeq; NP_115892.2; NM_032503.2.
DR AlphaFoldDB; Q969V1; -.
DR SMR; Q969V1; -.
DR BioGRID; 124126; 1.
DR STRING; 9606.ENSP00000281806; -.
DR BindingDB; Q969V1; -.
DR ChEMBL; CHEMBL5038; -.
DR GuidetoPHARMACOLOGY; 281; -.
DR GlyGen; Q969V1; 2 sites.
DR BioMuta; MCHR2; -.
DR DMDM; 34098673; -.
DR PaxDb; Q969V1; -.
DR PeptideAtlas; Q969V1; -.
DR PRIDE; Q969V1; -.
DR ProteomicsDB; 75849; -.
DR Antibodypedia; 32028; 203 antibodies from 28 providers.
DR DNASU; 84539; -.
DR Ensembl; ENST00000281806.7; ENSP00000281806.2; ENSG00000152034.11.
DR Ensembl; ENST00000369212.2; ENSP00000358214.1; ENSG00000152034.11.
DR GeneID; 84539; -.
DR KEGG; hsa:84539; -.
DR MANE-Select; ENST00000281806.7; ENSP00000281806.2; NM_001040179.2; NP_001035269.1.
DR UCSC; uc003pqh.1; human.
DR CTD; 84539; -.
DR DisGeNET; 84539; -.
DR GeneCards; MCHR2; -.
DR HGNC; HGNC:20867; MCHR2.
DR HPA; ENSG00000152034; Group enriched (brain, testis).
DR MIM; 606111; gene.
DR neXtProt; NX_Q969V1; -.
DR OpenTargets; ENSG00000152034; -.
DR PharmGKB; PA134950856; -.
DR VEuPathDB; HostDB:ENSG00000152034; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000154272; -.
DR HOGENOM; CLU_009579_8_1_1; -.
DR InParanoid; Q969V1; -.
DR OMA; SCAFDLA; -.
DR OrthoDB; 1011272at2759; -.
DR PhylomeDB; Q969V1; -.
DR TreeFam; TF315737; -.
DR PathwayCommons; Q969V1; -.
DR Reactome; R-HSA-375276; Peptide ligand-binding receptors.
DR Reactome; R-HSA-416476; G alpha (q) signalling events.
DR Reactome; R-HSA-418594; G alpha (i) signalling events.
DR SignaLink; Q969V1; -.
DR SIGNOR; Q969V1; -.
DR BioGRID-ORCS; 84539; 10 hits in 1060 CRISPR screens.
DR GeneWiki; Melanin-concentrating_hormone_receptor_2; -.
DR GenomeRNAi; 84539; -.
DR Pharos; Q969V1; Tchem.
DR PRO; PR:Q969V1; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q969V1; protein.
DR Bgee; ENSG00000152034; Expressed in prefrontal cortex and 30 other tissues.
DR Genevisible; Q969V1; HS.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0008528; F:G protein-coupled peptide receptor activity; IBA:GO_Central.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR008362; MCH2_receptor.
DR InterPro; IPR008361; MCH_rcpt.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01784; MCH2RECEPTOR.
DR PRINTS; PR01783; MCHRECEPTOR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..340
FT /note="Melanin-concentrating hormone receptor 2"
FT /id="PRO_0000069740"
FT TOPO_DOM 1..39
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 40..60
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 61..69
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 91..104
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..129
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 130..154
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..175
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 176..200
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 201..221
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 222..252
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 253..273
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 274..288
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 289..309
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 310..340
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 10
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 17
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 63
FT /note="R -> K (no changes in receptor binding or functional
FT signaling; dbSNP:rs147988902)"
FT /evidence="ECO:0000269|PubMed:15340116"
FT /id="VAR_026661"
FT VARIANT 152
FT /note="R -> Q (no changes in receptor binding or functional
FT signaling; dbSNP:rs62434070)"
FT /evidence="ECO:0000269|PubMed:15340116"
FT /id="VAR_026662"
SQ SEQUENCE 340 AA; 38849 MW; 754A302BB951FAC6 CRC64;
MNPFHASCWN TSAELLNKSW NKEFAYQTAS VVDTVILPSM IGIICSTGLV GNILIVFTII
RSRKKTVPDI YICNLAVADL VHIVGMPFLI HQWARGGEWV FGGPLCTIIT SLDTCNQFAC
SAIMTVMSVD RYFALVQPFR LTRWRTRYKT IRINLGLWAA SFILALPVWV YSKVIKFKDG
VESCAFDLTS PDDVLWYTLY LTITTFFFPL PLILVCYILI LCYTWEMYQQ NKDARCCNPS
VPKQRVMKLT KMVLVLVVVF ILSAAPYHVI QLVNLQMEQP TLAFYVGYYL SICLSYASSS
INPFLYILLS GNFQKRLPQI QRRATEKEIN NMGNTLKSHF
