ID   MCHR2_MACFA             Reviewed;         340 AA.
AC   Q8SQ54;
DT   15-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Melanin-concentrating hormone receptor 2;
DE            Short=MCH receptor 2;
DE            Short=MCH-R2;
DE            Short=MCHR-2;
DE   AltName: Full=G-protein coupled receptor 145;
DE   AltName: Full=GPRv17;
DE   AltName: Full=MCH-2R;
DE            Short=MCH2;
DE            Short=MCH2R;
GN   Name=MCHR2; Synonyms=GPR145;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Kurama T., Matsumoto S., Takasaki J., Terai K., Matsumoto M., Kamohara M.,
RA   Saito T., Soga T., Saito Y., Oda T., Masuho Y., Furuichi K.;
RT   "Molecular characterization of a novel melanin-concentrating hormone
RT   receptor: evidence of its expression in lateral hypothalamus.";
RL   Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Receptor for melanin-concentrating hormone, coupled to G
CC       proteins that activate phosphoinositide hydrolysis.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AB058850; BAB87843.1; -; mRNA.
DR   RefSeq; NP_001306455.1; NM_001319526.1.
DR   AlphaFoldDB; Q8SQ54; -.
DR   SMR; Q8SQ54; -.
DR   STRING; 9541.XP_005552336.1; -.
DR   GeneID; 102142845; -.
DR   CTD; 84539; -.
DR   eggNOG; KOG3656; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR008362; MCH2_receptor.
DR   InterPro; IPR008361; MCH_rcpt.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01784; MCH2RECEPTOR.
DR   PRINTS; PR01783; MCHRECEPTOR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW   Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..340
FT                   /note="Melanin-concentrating hormone receptor 2"
FT                   /id="PRO_0000069741"
FT   TOPO_DOM        1..34
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        35..57
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        58..69
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        70..92
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        93..106
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        107..129
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        130..149
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..172
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        173..198
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        199..221
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        222..252
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        253..272
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        273..286
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        287..309
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        310..340
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        10
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        17
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   340 AA;  38770 MW;  BD22CF1972332439 CRC64;
     MNPFHSSCWN TSAELSNKSW NKEFAYQTAS AVDTVILPSM IGIICSTGLV GNILIVFTII
     RSRKKTVPDI YICNLAVADL VHIIGMPFLI HQWARGGEWV FGGPLCTIIT SLDTCNQFAC
     SAIMTVMSVD RYFALVQPFR LTSWRTRYKT IRINLGLWAA SFILALPVWI YSKVIKFKDG
     VESCAFDLTS PDDVLWYTLY LTITTFFFPL PLILVCYILI LCYTWEMYQQ NKDARCCNPS
     VPKQRVMKLT KMVLVLVAVF ILSAAPYHVI QLVNLQMEQP TLAFYVGYYL SICLSYASSS
     INPFLYILLS GNFQKRLPQI QRRVTDKEIK NMGNTLKSHF