MCHR2_MACMU
ID MCHR2_MACMU Reviewed; 340 AA.
AC Q8MJ88;
DT 15-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Melanin-concentrating hormone receptor 2;
DE Short=MCH receptor 2;
DE Short=MCH-R2;
DE Short=MCHR-2;
DE AltName: Full=G-protein coupled receptor 145;
DE AltName: Full=MCH-2R;
DE Short=MCH2;
DE Short=MCH2R;
GN Name=MCHR2; Synonyms=GPR145;
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12182940; DOI=10.1016/s0196-9781(02)00077-3;
RA Fried S., O'Neill K., Hawes B.E.;
RT "Cloning and characterization of rhesus monkey MCH-R1 and MCH-R2.";
RL Peptides 23:1401-1408(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12036292; DOI=10.1006/geno.2002.6771;
RA Tan C.P., Sano H., Iwaasa H., Pan J., Sailer A.W., Hreniuk D.L.,
RA Feighner S.D., Palyha O.C., Pong S.S., Figueroa D.J., Austin C.P.,
RA Jiang M.M., Yu H., Ito J., Ito M., Ito M., Guan X.M., MacNeil D.J.,
RA Kanatani A., Van der Ploeg L.H.T., Howard A.D.;
RT "Melanin-concentrating hormone receptor subtypes 1 and 2: species-specific
RT gene expression.";
RL Genomics 79:785-792(2002).
CC -!- FUNCTION: Receptor for melanin-concentrating hormone, coupled to G
CC proteins that activate phosphoinositide hydrolysis.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Specifically expressed in the brain with highest
CC levels in cerebral cortex, hippocampus and hypothalamus, and lower
CC levels in caudate nucleus, putamen and thalamus.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY078246; AAL80004.1; -; mRNA.
DR EMBL; AF513989; AAM49794.1; -; mRNA.
DR RefSeq; NP_001028120.1; NM_001032948.1.
DR RefSeq; XP_014992431.1; XM_015136945.1.
DR RefSeq; XP_014992432.1; XM_015136946.1.
DR RefSeq; XP_014992433.1; XM_015136947.1.
DR AlphaFoldDB; Q8MJ88; -.
DR SMR; Q8MJ88; -.
DR STRING; 9544.ENSMMUP00000001100; -.
DR Ensembl; ENSMMUT00000001172; ENSMMUP00000001100; ENSMMUG00000000808.
DR Ensembl; ENSMMUT00000083186; ENSMMUP00000078585; ENSMMUG00000000808.
DR GeneID; 574369; -.
DR KEGG; mcc:574369; -.
DR CTD; 84539; -.
DR VEuPathDB; HostDB:ENSMMUG00000000808; -.
DR VGNC; VGNC:74550; MCHR2.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000154272; -.
DR HOGENOM; CLU_009579_8_1_1; -.
DR InParanoid; Q8MJ88; -.
DR OMA; SCAFDLA; -.
DR OrthoDB; 1011272at2759; -.
DR TreeFam; TF315737; -.
DR Proteomes; UP000006718; Chromosome 4.
DR Bgee; ENSMMUG00000000808; Expressed in spermatid and 6 other tissues.
DR ExpressionAtlas; Q8MJ88; baseline.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0008528; F:G protein-coupled peptide receptor activity; IBA:GO_Central.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR008362; MCH2_receptor.
DR InterPro; IPR008361; MCH_rcpt.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01784; MCH2RECEPTOR.
DR PRINTS; PR01783; MCHRECEPTOR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..340
FT /note="Melanin-concentrating hormone receptor 2"
FT /id="PRO_0000069742"
FT TOPO_DOM 1..34
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 35..57
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 58..69
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..92
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 93..106
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 107..129
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 130..149
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..172
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 173..198
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..221
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 222..252
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 253..272
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 273..286
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 287..309
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 310..340
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 10
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 17
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 340 AA; 38784 MW; 17AC576CCF8FA758 CRC64;
MNPFHSSCWN TSAELSNKSW NKEFAYQTAS VVDTVILPSM IGIICSTGLV GNILIVFTII
RSRKKTVPDI YICNLAVADL VHIIGMPFLI HQWARGGEWV FGGPLCTIIT SLDTCNQFAC
SAIMTVMSVD RYFALVQPFR LTSWRTRYKT IRINLGLWAA SFVLALPVWI YSKVIKFKDG
VESCAFDLTS PDDVLWYTLY LTITTFFFPL PLILVCYILI LCYTWEMYQQ NKDARCCNPS
VPKQRVMKLT KMVLVLVAVF ILSAAPYHVI QLVNLQMEQP TLAFYVGYYL SICLSYASSS
INPFLYILLS GNFQKRLPQI QRRVTDKEIK NMGNTLKSHF
