ID   MCH_HALS3               Reviewed;         311 AA.
AC   B0R653;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Methenyltetrahydromethanopterin cyclohydrolase {ECO:0000255|HAMAP-Rule:MF_00486};
DE            EC=3.5.4.27 {ECO:0000255|HAMAP-Rule:MF_00486};
DE   AltName: Full=Methenyl-H4MPT cyclohydrolase {ECO:0000255|HAMAP-Rule:MF_00486};
GN   Name=mch {ECO:0000255|HAMAP-Rule:MF_00486}; OrderedLocusNames=OE_3383R;
OS   Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=478009;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29341 / DSM 671 / R1;
RX   PubMed=18313895; DOI=10.1016/j.ygeno.2008.01.001;
RA   Pfeiffer F., Schuster S.C., Broicher A., Falb M., Palm P., Rodewald K.,
RA   Ruepp A., Soppa J., Tittor J., Oesterhelt D.;
RT   "Evolution in the laboratory: the genome of Halobacterium salinarum strain
RT   R1 compared to that of strain NRC-1.";
RL   Genomics 91:335-346(2008).
CC   -!- FUNCTION: Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl-
CC       H(4)MPT. {ECO:0000255|HAMAP-Rule:MF_00486}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = H(+) +
CC         N(5)-formyl-5,6,7,8-tetrahydromethanopterin; Xref=Rhea:RHEA:19053,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58018,
CC         ChEBI:CHEBI:58337; EC=3.5.4.27; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00486};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00486}.
CC   -!- SIMILARITY: Belongs to the MCH family. {ECO:0000255|HAMAP-
CC       Rule:MF_00486}.
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DR   EMBL; AM774415; CAP14222.1; -; Genomic_DNA.
DR   RefSeq; WP_010903231.1; NC_010364.1.
DR   AlphaFoldDB; B0R653; -.
DR   SMR; B0R653; -.
DR   EnsemblBacteria; CAP14222; CAP14222; OE_3383R.
DR   GeneID; 5953669; -.
DR   GeneID; 62884942; -.
DR   KEGG; hsl:OE_3383R; -.
DR   HOGENOM; CLU_876031_0_0_2; -.
DR   OMA; DKGMFAP; -.
DR   PhylomeDB; B0R653; -.
DR   Proteomes; UP000001321; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0018759; F:methenyltetrahydromethanopterin cyclohydrolase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd00545; MCH; 1.
DR   HAMAP; MF_00486; McH; 1.
DR   InterPro; IPR003209; METHMP_CycHdrlase.
DR   Pfam; PF02289; MCH; 1.
DR   TIGRFAMs; TIGR03120; one_C_mch; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Hydrolase; One-carbon metabolism.
FT   CHAIN           1..311
FT                   /note="Methenyltetrahydromethanopterin cyclohydrolase"
FT                   /id="PRO_1000126119"
SQ   SEQUENCE   311 AA;  32140 MW;  57A250AAE0E2D3AE CRC64;
     MESLNRMALE LADEALEFTE ELDIGAFELD TGTTVIDFGV EHDGGLEAGL LLAELQTAGL
     ATVQTRVDTV GDATFPHVEV ACDQPAVAML GAQKAGWELA VDDYEALGSG PARALVATEG
     EFQAIDYVDA FEFAVLTLES TGLPTTAAAS EVAARAGVTE ESVFLPTYRT ASVAGSVSAA
     ARTVELAVFR LYELGYDPTD VLSASGCAPV APVAGDEQTA IGRTNDALAH GGRVHLTVAE
     DFDAFDAVVS SAAARYDDPF AEVVGTDDWD AGDVDNGVFG PAQLTVDVVG GPTHAFGTVR
     EDVLADGFGL S