ID   MCH_HALSA               Reviewed;         311 AA.
AC   Q9HPD7;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Methenyltetrahydromethanopterin cyclohydrolase;
DE            EC=3.5.4.27;
DE   AltName: Full=Methenyl-H4MPT cyclohydrolase;
GN   Name=mch; OrderedLocusNames=VNG_1686G;
OS   Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS   (Halobacterium halobium).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=64091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=11016950; DOI=10.1073/pnas.190337797;
RA   Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA   Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA   Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA   Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA   Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA   Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA   Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA   DasSarma S.;
RT   "Genome sequence of Halobacterium species NRC-1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
CC   -!- FUNCTION: Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl-
CC       H(4)MPT. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = H(+) +
CC         N(5)-formyl-5,6,7,8-tetrahydromethanopterin; Xref=Rhea:RHEA:19053,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58018,
CC         ChEBI:CHEBI:58337; EC=3.5.4.27;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MCH family. {ECO:0000305}.
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DR   EMBL; AE004437; AAG19933.1; -; Genomic_DNA.
DR   PIR; A84321; A84321.
DR   RefSeq; WP_010903231.1; NC_002607.1.
DR   AlphaFoldDB; Q9HPD7; -.
DR   SMR; Q9HPD7; -.
DR   STRING; 64091.VNG_1686G; -.
DR   PaxDb; Q9HPD7; -.
DR   EnsemblBacteria; AAG19933; AAG19933; VNG_1686G.
DR   GeneID; 5953669; -.
DR   GeneID; 62884942; -.
DR   KEGG; hal:VNG_1686G; -.
DR   PATRIC; fig|64091.14.peg.1285; -.
DR   HOGENOM; CLU_876031_0_0_2; -.
DR   InParanoid; Q9HPD7; -.
DR   OMA; DKGMFAP; -.
DR   OrthoDB; 31274at2157; -.
DR   PhylomeDB; Q9HPD7; -.
DR   Proteomes; UP000000554; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0018759; F:methenyltetrahydromethanopterin cyclohydrolase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd00545; MCH; 1.
DR   HAMAP; MF_00486; McH; 1.
DR   InterPro; IPR003209; METHMP_CycHdrlase.
DR   Pfam; PF02289; MCH; 1.
DR   TIGRFAMs; TIGR03120; one_C_mch; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Hydrolase; One-carbon metabolism; Reference proteome.
FT   CHAIN           1..311
FT                   /note="Methenyltetrahydromethanopterin cyclohydrolase"
FT                   /id="PRO_0000140878"
SQ   SEQUENCE   311 AA;  32140 MW;  57A250AAE0E2D3AE CRC64;
     MESLNRMALE LADEALEFTE ELDIGAFELD TGTTVIDFGV EHDGGLEAGL LLAELQTAGL
     ATVQTRVDTV GDATFPHVEV ACDQPAVAML GAQKAGWELA VDDYEALGSG PARALVATEG
     EFQAIDYVDA FEFAVLTLES TGLPTTAAAS EVAARAGVTE ESVFLPTYRT ASVAGSVSAA
     ARTVELAVFR LYELGYDPTD VLSASGCAPV APVAGDEQTA IGRTNDALAH GGRVHLTVAE
     DFDAFDAVVS SAAARYDDPF AEVVGTDDWD AGDVDNGVFG PAQLTVDVVG GPTHAFGTVR
     EDVLADGFGL S