ID   MCH_METAC               Reviewed;         321 AA.
AC   Q8TQ42;
DT   02-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 111.
DE   RecName: Full=Methenyltetrahydromethanopterin cyclohydrolase {ECO:0000255|HAMAP-Rule:MF_00486};
DE            EC=3.5.4.27 {ECO:0000255|HAMAP-Rule:MF_00486};
DE   AltName: Full=Methenyl-H4MPT cyclohydrolase {ECO:0000255|HAMAP-Rule:MF_00486};
GN   Name=mch {ECO:0000255|HAMAP-Rule:MF_00486}; OrderedLocusNames=MA_1710;
OS   Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 /
OS   C2A).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=188937;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35395 / DSM 2834 / JCM 12185 / C2A;
RX   PubMed=11932238; DOI=10.1101/gr.223902;
RA   Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W.,
RA   Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J.,
RA   Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P.,
RA   McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D.,
RA   Cann I., Graham D.E., Grahame D.A., Guss A.M., Hedderich R.,
RA   Ingram-Smith C., Kuettner H.C., Krzycki J.A., Leigh J.A., Li W., Liu J.,
RA   Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A.,
RA   White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H.,
RA   Macario A.J.L., Paulsen I.T., Pritchett M., Sowers K.R., Swanson R.V.,
RA   Zinder S.H., Lander E., Metcalf W.W., Birren B.;
RT   "The genome of Methanosarcina acetivorans reveals extensive metabolic and
RT   physiological diversity.";
RL   Genome Res. 12:532-542(2002).
CC   -!- FUNCTION: Catalyzes the reversible interconversion of 5-formyl-H(4)MPT
CC       to methenyl-H(4)MPT(+). {ECO:0000255|HAMAP-Rule:MF_00486}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = H(+) +
CC         N(5)-formyl-5,6,7,8-tetrahydromethanopterin; Xref=Rhea:RHEA:19053,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58018,
CC         ChEBI:CHEBI:58337; EC=3.5.4.27; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00486};
CC   -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); 5,10-
CC       methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 3/3.
CC       {ECO:0000255|HAMAP-Rule:MF_00486}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00486}.
CC   -!- SIMILARITY: Belongs to the MCH family. {ECO:0000255|HAMAP-
CC       Rule:MF_00486}.
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DR   EMBL; AE010299; AAM05117.1; -; Genomic_DNA.
DR   RefSeq; WP_011021714.1; NC_003552.1.
DR   AlphaFoldDB; Q8TQ42; -.
DR   SMR; Q8TQ42; -.
DR   STRING; 188937.MA_1710; -.
DR   EnsemblBacteria; AAM05117; AAM05117; MA_1710.
DR   GeneID; 1473598; -.
DR   KEGG; mac:MA_1710; -.
DR   HOGENOM; CLU_876031_0_0_2; -.
DR   InParanoid; Q8TQ42; -.
DR   OMA; DKGMFAP; -.
DR   OrthoDB; 31274at2157; -.
DR   PhylomeDB; Q8TQ42; -.
DR   UniPathway; UPA00640; UER00694.
DR   Proteomes; UP000002487; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0018759; F:methenyltetrahydromethanopterin cyclohydrolase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019386; P:methanogenesis, from carbon dioxide; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd00545; MCH; 1.
DR   HAMAP; MF_00486; McH; 1.
DR   InterPro; IPR003209; METHMP_CycHdrlase.
DR   Pfam; PF02289; MCH; 1.
DR   TIGRFAMs; TIGR03120; one_C_mch; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Hydrolase; Methanogenesis; One-carbon metabolism;
KW   Reference proteome.
FT   CHAIN           1..321
FT                   /note="Methenyltetrahydromethanopterin cyclohydrolase"
FT                   /id="PRO_0000140879"
SQ   SEQUENCE   321 AA;  34886 MW;  37078E0AD6C3957D CRC64;
     MISVNEMGSY VIEEMLDWSE DLKTEVTKLN SGATIIDCGV KAEGGYEAGM YLARLCLGDL
     ADLKYSTFDL NGIKWPAIQV ATDNPLIACM ASQYAGWRIS VGDYFGMGSG PARALGLKPK
     ELYEEIGYED DFEVAVLVME SDKLPDEKVV EYIAKHCGVE PENVMIAVAP TASIAGSVQI
     SARVVETGIH KFESIGFDIN CIKSGYGIAP IAPVVGNDVQ CMGSTNDCVI YCGETNYTVR
     FEGELAELED FVKKVPSTTS NDFGKPFYQT FKAANFDFFK VDAGMFAPAR VTVNDLKSTK
     TISSGGLYPE ILLESFGIRN V