ID   MCH_METBF               Reviewed;         321 AA.
AC   P94919; Q46AD4;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   25-MAY-2022, entry version 129.
DE   RecName: Full=Methenyltetrahydromethanopterin cyclohydrolase;
DE            EC=3.5.4.27;
DE   AltName: Full=Methenyl-H4MPT cyclohydrolase;
GN   Name=mch; OrderedLocusNames=Mbar_A2233;
OS   Methanosarcina barkeri (strain Fusaro / DSM 804).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=269797;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Vaupel M.;
RL   Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Fusaro / DSM 804;
RX   PubMed=16980466; DOI=10.1128/jb.00810-06;
RA   Maeder D.L., Anderson I., Brettin T.S., Bruce D.C., Gilna P., Han C.S.,
RA   Lapidus A., Metcalf W.W., Saunders E., Tapia R., Sowers K.R.;
RT   "The Methanosarcina barkeri genome: comparative analysis with
RT   Methanosarcina acetivorans and Methanosarcina mazei reveals extensive
RT   rearrangement within methanosarcinal genomes.";
RL   J. Bacteriol. 188:7922-7931(2006).
CC   -!- FUNCTION: Catalyzes the reversible interconversion of 5-formyl-H(4)MPT
CC       to methenyl-H(4)MPT(+). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = H(+) +
CC         N(5)-formyl-5,6,7,8-tetrahydromethanopterin; Xref=Rhea:RHEA:19053,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58018,
CC         ChEBI:CHEBI:58337; EC=3.5.4.27;
CC   -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); 5,10-
CC       methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 3/3.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MCH family. {ECO:0000305}.
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DR   EMBL; Y08843; CAA70069.1; -; Genomic_DNA.
DR   EMBL; CP000099; AAZ71158.1; -; Genomic_DNA.
DR   RefSeq; WP_011307204.1; NC_007355.1.
DR   AlphaFoldDB; P94919; -.
DR   SMR; P94919; -.
DR   STRING; 269797.Mbar_A2233; -.
DR   EnsemblBacteria; AAZ71158; AAZ71158; Mbar_A2233.
DR   GeneID; 3624695; -.
DR   KEGG; mba:Mbar_A2233; -.
DR   eggNOG; arCOG02675; Archaea.
DR   HOGENOM; CLU_876031_0_0_2; -.
DR   OMA; DKGMFAP; -.
DR   OrthoDB; 31274at2157; -.
DR   UniPathway; UPA00640; UER00694.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0018759; F:methenyltetrahydromethanopterin cyclohydrolase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019386; P:methanogenesis, from carbon dioxide; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd00545; MCH; 1.
DR   HAMAP; MF_00486; McH; 1.
DR   InterPro; IPR003209; METHMP_CycHdrlase.
DR   Pfam; PF02289; MCH; 1.
DR   TIGRFAMs; TIGR03120; one_C_mch; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Hydrolase; Methanogenesis; One-carbon metabolism.
FT   CHAIN           1..321
FT                   /note="Methenyltetrahydromethanopterin cyclohydrolase"
FT                   /id="PRO_0000140880"
SQ   SEQUENCE   321 AA;  34904 MW;  89601E7C21F4E7F7 CRC64;
     MISVNEMGSN VIEEMLDWSE DLKTEVLKLN NGATVIDCGV KAEGGYEAGM YLARLCLADL
     ADLKYTTFDL NGLKWPAIQV ATDNPVIACM ASQYAGWRIS VGNYFGMGSG PARALGLKPK
     ELYEEIGYED DFEAAVLVME SDKLPDEKVV EFIAKHCSVD PENVMIAVAP TASIAGSVQI
     SARVVETGIH KFESVGFDIN CIKSGYGVAP IAPVVGKDVQ CMGSTNDCVI YCGETNYTVR
     FDGELAELEE FVKKVPSTTS QDFGKPFYQT FKEANFDFFK VDAGMFAPAR LTVNDLNSTK
     TISSGGLYPE ILLQSFGIRN V