MCH_METLZ
ID MCH_METLZ Reviewed; 314 AA.
AC A2SQG9;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 06-MAR-2007, sequence version 1.
DT 25-MAY-2022, entry version 76.
DE RecName: Full=Methenyltetrahydromethanopterin cyclohydrolase {ECO:0000255|HAMAP-Rule:MF_00486};
DE EC=3.5.4.27 {ECO:0000255|HAMAP-Rule:MF_00486};
DE AltName: Full=Methenyl-H4MPT cyclohydrolase {ECO:0000255|HAMAP-Rule:MF_00486};
GN Name=mch {ECO:0000255|HAMAP-Rule:MF_00486}; OrderedLocusNames=Mlab_0399;
OS Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanomicrobiales; Methanocorpusculaceae; Methanocorpusculum.
OX NCBI_TaxID=410358;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43576 / DSM 4855 / Z;
RX PubMed=21304657; DOI=10.4056/sigs.35575;
RA Anderson I.J., Sieprawska-Lupa M., Goltsman E., Lapidus A., Copeland A.,
RA Glavina Del Rio T., Tice H., Dalin E., Barry K., Pitluck S., Hauser L.,
RA Land M., Lucas S., Richardson P., Whitman W.B., Kyrpides N.C.;
RT "Complete genome sequence of Methanocorpusculum labreanum type strain Z.";
RL Stand. Genomic Sci. 1:197-203(2009).
CC -!- FUNCTION: Catalyzes the reversible interconversion of 5-formyl-H(4)MPT
CC to methenyl-H(4)MPT(+). {ECO:0000255|HAMAP-Rule:MF_00486}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = H(+) +
CC N(5)-formyl-5,6,7,8-tetrahydromethanopterin; Xref=Rhea:RHEA:19053,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58018,
CC ChEBI:CHEBI:58337; EC=3.5.4.27; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_00486};
CC -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); 5,10-
CC methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 3/3.
CC {ECO:0000255|HAMAP-Rule:MF_00486}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00486}.
CC -!- SIMILARITY: Belongs to the MCH family. {ECO:0000255|HAMAP-
CC Rule:MF_00486}.
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DR EMBL; CP000559; ABN06575.1; -; Genomic_DNA.
DR RefSeq; WP_011832776.1; NC_008942.1.
DR AlphaFoldDB; A2SQG9; -.
DR SMR; A2SQG9; -.
DR STRING; 410358.Mlab_0399; -.
DR EnsemblBacteria; ABN06575; ABN06575; Mlab_0399.
DR GeneID; 4794649; -.
DR KEGG; mla:Mlab_0399; -.
DR eggNOG; arCOG02675; Archaea.
DR HOGENOM; CLU_876031_0_0_2; -.
DR OMA; DKGMFAP; -.
DR OrthoDB; 31274at2157; -.
DR UniPathway; UPA00640; UER00694.
DR Proteomes; UP000000365; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0018759; F:methenyltetrahydromethanopterin cyclohydrolase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019386; P:methanogenesis, from carbon dioxide; IEA:UniProtKB-UniPathway.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd00545; MCH; 1.
DR HAMAP; MF_00486; McH; 1.
DR InterPro; IPR003209; METHMP_CycHdrlase.
DR Pfam; PF02289; MCH; 1.
DR TIGRFAMs; TIGR03120; one_C_mch; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Hydrolase; Methanogenesis; One-carbon metabolism;
KW Reference proteome.
FT CHAIN 1..314
FT /note="Methenyltetrahydromethanopterin cyclohydrolase"
FT /id="PRO_1000014399"
SQ SEQUENCE 314 AA; 33489 MW; 60B10D25DF43141C CRC64;
MVSVNELGLD LFEELVENAD LFNVAYHELD NGSRVVDCGV SVPGGYGAGD YFTRICMGGL
GDIAFRQGMV GQFPMTFIDV NTDFPAISCL GSQKAGWTVK HDNFFAMGSG PARALSLQPK
HTFEVIGYED ESDAAVICLE ADRLPSGAVM EMIAEKCKVD VANVCALVAP TSSLVGSIQV
AGRCVETAVY KLNELGFDTT KIIAAAGTAP IPPVRGAKLA MGVTNDATIY HGQINLTMNA
PEIVDYLEKI PSCSSNGYGK PFNDIFKEAG YDFYKIDKSL FSPAEVIINE VSTGKVYQVG
KVDTAVTLKS FGLA
