ID   MCH_METM5               Reviewed;         323 AA.
AC   A4FWY5;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   17-APR-2007, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Methenyltetrahydromethanopterin cyclohydrolase {ECO:0000255|HAMAP-Rule:MF_00486};
DE            EC=3.5.4.27 {ECO:0000255|HAMAP-Rule:MF_00486};
DE   AltName: Full=Methenyl-H4MPT cyclohydrolase {ECO:0000255|HAMAP-Rule:MF_00486};
GN   Name=mch {ECO:0000255|HAMAP-Rule:MF_00486}; OrderedLocusNames=MmarC5_0399;
OS   Methanococcus maripaludis (strain C5 / ATCC BAA-1333).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanococcaceae; Methanococcus.
OX   NCBI_TaxID=402880;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C5 / ATCC BAA-1333;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C.,
RA   Detter J.C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Sieprawska-Lupa M., Whitman W.B., Richardson P.;
RT   "Complete sequence of chromosome of Methanococcus maripaludis C5.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the reversible interconversion of 5-formyl-H(4)MPT
CC       to methenyl-H(4)MPT(+). {ECO:0000255|HAMAP-Rule:MF_00486}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = H(+) +
CC         N(5)-formyl-5,6,7,8-tetrahydromethanopterin; Xref=Rhea:RHEA:19053,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58018,
CC         ChEBI:CHEBI:58337; EC=3.5.4.27; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00486};
CC   -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); 5,10-
CC       methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 3/3.
CC       {ECO:0000255|HAMAP-Rule:MF_00486}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00486}.
CC   -!- SIMILARITY: Belongs to the MCH family. {ECO:0000255|HAMAP-
CC       Rule:MF_00486}.
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DR   EMBL; CP000609; ABO34714.1; -; Genomic_DNA.
DR   RefSeq; WP_011868169.1; NC_009135.1.
DR   AlphaFoldDB; A4FWY5; -.
DR   SMR; A4FWY5; -.
DR   STRING; 402880.MmarC5_0399; -.
DR   EnsemblBacteria; ABO34714; ABO34714; MmarC5_0399.
DR   GeneID; 4928850; -.
DR   KEGG; mmq:MmarC5_0399; -.
DR   eggNOG; arCOG02675; Archaea.
DR   HOGENOM; CLU_876031_0_0_2; -.
DR   OMA; DKGMFAP; -.
DR   OrthoDB; 31274at2157; -.
DR   UniPathway; UPA00640; UER00694.
DR   Proteomes; UP000000253; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0018759; F:methenyltetrahydromethanopterin cyclohydrolase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019386; P:methanogenesis, from carbon dioxide; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd00545; MCH; 1.
DR   HAMAP; MF_00486; McH; 1.
DR   InterPro; IPR003209; METHMP_CycHdrlase.
DR   Pfam; PF02289; MCH; 1.
DR   TIGRFAMs; TIGR03120; one_C_mch; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Hydrolase; Methanogenesis; One-carbon metabolism.
FT   CHAIN           1..323
FT                   /note="Methenyltetrahydromethanopterin cyclohydrolase"
FT                   /id="PRO_1000014400"
SQ   SEQUENCE   323 AA;  34776 MW;  1268BEA188AD7E69 CRC64;
     MISVNLASLP IVEDMINRKE DLNIEVIKLE NGATVLDCGV NVMGSFEAGK LFTKICLGGL
     AHVGISISGS LDNKLVLPCV KIKTSHPAIA TLGAQKAGWS VSVGKYFAMG SGPARALAMM
     PKATYEEIDY KDEADVAILC LESSQLPDEN VADHVAEKCG VDVSKVYLLV APTASMVGAV
     QISGRVVENG TYKMLEALHF DVRKVKFAAG IAPVAPVIGD DLKMMGATND MVLYGGRTYY
     YVKSDEGDDI ENLCKSLPSC SAETYGKPFL DVFKEANYDF YKIDKGIFAP AVVTINDLRT
     GKLMSYGETN VDVIKKSLKF SQL