MCH_METMA
ID MCH_METMA Reviewed; 321 AA.
AC Q8PTR0;
DT 10-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 10-OCT-2002, sequence version 1.
DT 25-MAY-2022, entry version 120.
DE RecName: Full=Methenyltetrahydromethanopterin cyclohydrolase {ECO:0000255|HAMAP-Rule:MF_00486};
DE EC=3.5.4.27 {ECO:0000255|HAMAP-Rule:MF_00486};
DE AltName: Full=Methenyl-H4MPT cyclohydrolase {ECO:0000255|HAMAP-Rule:MF_00486};
GN Name=mch {ECO:0000255|HAMAP-Rule:MF_00486}; OrderedLocusNames=MM_2653;
OS Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM
OS 11833 / OCM 88) (Methanosarcina frisia).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX NCBI_TaxID=192952;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88;
RX PubMed=12125824;
RA Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A.,
RA Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C.,
RA Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S.,
RA Bhattacharyya A., Lykidis A., Overbeek R., Klenk H.-P., Gunsalus R.P.,
RA Fritz H.-J., Gottschalk G.;
RT "The genome of Methanosarcina mazei: evidence for lateral gene transfer
RT between Bacteria and Archaea.";
RL J. Mol. Microbiol. Biotechnol. 4:453-461(2002).
CC -!- FUNCTION: Catalyzes the reversible interconversion of 5-formyl-H(4)MPT
CC to methenyl-H(4)MPT(+). {ECO:0000255|HAMAP-Rule:MF_00486}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = H(+) +
CC N(5)-formyl-5,6,7,8-tetrahydromethanopterin; Xref=Rhea:RHEA:19053,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58018,
CC ChEBI:CHEBI:58337; EC=3.5.4.27; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_00486};
CC -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); 5,10-
CC methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 3/3.
CC {ECO:0000255|HAMAP-Rule:MF_00486}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00486}.
CC -!- SIMILARITY: Belongs to the MCH family. {ECO:0000255|HAMAP-
CC Rule:MF_00486}.
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DR EMBL; AE008384; AAM32349.1; -; Genomic_DNA.
DR RefSeq; WP_011034564.1; NC_003901.1.
DR AlphaFoldDB; Q8PTR0; -.
DR SMR; Q8PTR0; -.
DR STRING; 192952.MM_2653; -.
DR EnsemblBacteria; AAM32349; AAM32349; MM_2653.
DR GeneID; 44088034; -.
DR GeneID; 66134523; -.
DR KEGG; mma:MM_2653; -.
DR PATRIC; fig|192952.21.peg.3053; -.
DR eggNOG; arCOG02675; Archaea.
DR HOGENOM; CLU_876031_0_0_2; -.
DR OMA; DKGMFAP; -.
DR UniPathway; UPA00640; UER00694.
DR Proteomes; UP000000595; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0018759; F:methenyltetrahydromethanopterin cyclohydrolase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019386; P:methanogenesis, from carbon dioxide; IEA:UniProtKB-UniPathway.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd00545; MCH; 1.
DR HAMAP; MF_00486; McH; 1.
DR InterPro; IPR003209; METHMP_CycHdrlase.
DR Pfam; PF02289; MCH; 1.
DR TIGRFAMs; TIGR03120; one_C_mch; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Hydrolase; Methanogenesis; One-carbon metabolism;
KW Reference proteome.
FT CHAIN 1..321
FT /note="Methenyltetrahydromethanopterin cyclohydrolase"
FT /id="PRO_0000140883"
SQ SEQUENCE 321 AA; 34982 MW; E52D1A7D169FAA8E CRC64;
MISVNEMGSY VIEEMLDWSE DLKTEVIKLE NGATIIDCGI KAEGGYEAGM YLARLCLADL
ADLKYSTFDL NGIKWPAIQV ATDNPVIACM ASQYAGWRIS VGNYFGMGSG PARALGLKPK
ELYEEIGYED DFEAAVLVME SDKLPDEKVV EYIAKHCSVD PENVMIAVAP TASIAGSVQI
SARVVETGIH KFESIGFDIN CIKSGYGIAP IAPIVGNDVQ CMGSTNDCVI YCGETNYTVS
FEGELAKLED FVRKVPSTTS DDFGKPFYQT FKAANFDFFK VDAGMFAPAR VTVNDLKNKK
TISSGGLYPE ILLESFGIRK V
