ID   MCH_METMJ               Reviewed;         315 AA.
AC   A3CTA1;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Methenyltetrahydromethanopterin cyclohydrolase {ECO:0000255|HAMAP-Rule:MF_00486};
DE            EC=3.5.4.27 {ECO:0000255|HAMAP-Rule:MF_00486};
DE   AltName: Full=Methenyl-H4MPT cyclohydrolase {ECO:0000255|HAMAP-Rule:MF_00486};
GN   Name=mch {ECO:0000255|HAMAP-Rule:MF_00486}; OrderedLocusNames=Memar_0668;
OS   Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanomicrobiales; Methanomicrobiaceae; Methanoculleus.
OX   NCBI_TaxID=368407;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35101 / DSM 1498 / JR1;
RX   PubMed=21304656; DOI=10.4056/sigs.32535;
RA   Anderson I.J., Sieprawska-Lupa M., Lapidus A., Nolan M., Copeland A.,
RA   Glavina Del Rio T., Tice H., Dalin E., Barry K., Saunders E., Han C.,
RA   Brettin T., Detter J.C., Bruce D., Mikhailova N., Pitluck S., Hauser L.,
RA   Land M., Lucas S., Richardson P., Whitman W.B., Kyrpides N.C.;
RT   "Complete genome sequence of Methanoculleus marisnigri Romesser et al. 1981
RT   type strain JR1.";
RL   Stand. Genomic Sci. 1:189-196(2009).
CC   -!- FUNCTION: Catalyzes the reversible interconversion of 5-formyl-H(4)MPT
CC       to methenyl-H(4)MPT(+). {ECO:0000255|HAMAP-Rule:MF_00486}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = H(+) +
CC         N(5)-formyl-5,6,7,8-tetrahydromethanopterin; Xref=Rhea:RHEA:19053,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58018,
CC         ChEBI:CHEBI:58337; EC=3.5.4.27; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00486};
CC   -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); 5,10-
CC       methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 3/3.
CC       {ECO:0000255|HAMAP-Rule:MF_00486}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00486}.
CC   -!- SIMILARITY: Belongs to the MCH family. {ECO:0000255|HAMAP-
CC       Rule:MF_00486}.
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DR   EMBL; CP000562; ABN56601.1; -; Genomic_DNA.
DR   RefSeq; WP_011843512.1; NC_009051.1.
DR   AlphaFoldDB; A3CTA1; -.
DR   SMR; A3CTA1; -.
DR   STRING; 368407.Memar_0668; -.
DR   EnsemblBacteria; ABN56601; ABN56601; Memar_0668.
DR   GeneID; 4848201; -.
DR   KEGG; mem:Memar_0668; -.
DR   eggNOG; arCOG02675; Archaea.
DR   HOGENOM; CLU_876031_0_0_2; -.
DR   OMA; DKGMFAP; -.
DR   OrthoDB; 31274at2157; -.
DR   UniPathway; UPA00640; UER00694.
DR   Proteomes; UP000002146; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0018759; F:methenyltetrahydromethanopterin cyclohydrolase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019386; P:methanogenesis, from carbon dioxide; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd00545; MCH; 1.
DR   HAMAP; MF_00486; McH; 1.
DR   InterPro; IPR003209; METHMP_CycHdrlase.
DR   Pfam; PF02289; MCH; 1.
DR   TIGRFAMs; TIGR03120; one_C_mch; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Hydrolase; Methanogenesis; One-carbon metabolism.
FT   CHAIN           1..315
FT                   /note="Methenyltetrahydromethanopterin cyclohydrolase"
FT                   /id="PRO_1000014402"
SQ   SEQUENCE   315 AA;  34182 MW;  3D71C27D2D01FEAD CRC64;
     MLSVNELALD IFEELFEYAE ELHAVPHELD NGARIVDCGV STSGGYLTGR RFTEICMGGL
     GEVDISMGKI RDFPIPFIEV STDFPSIACL GAQKAGWTVN VNKYFAMGSG PARALSLKPK
     HTYEVIEYED EFDYAVICLE SDHLPNAAVM ENIAEACNVD VANTCAVVAP TASLVGSIQV
     AGRCVETAVY KLNELGFDTK KITAGIGHAP IAPVKKDGTK AMGSTNDATI YHGSIMLTMN
     APEIKDYLDK IPSNKSKGYG KPFYDIFKEA NFDFYQIDTS LFSPAEVVIN ELSEGKVYHV
     GAVNPEVTLK SFGFI