MCH_METS3
ID MCH_METS3 Reviewed; 323 AA.
AC A5UP00;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=Methenyltetrahydromethanopterin cyclohydrolase {ECO:0000255|HAMAP-Rule:MF_00486};
DE EC=3.5.4.27 {ECO:0000255|HAMAP-Rule:MF_00486};
DE AltName: Full=Methenyl-H4MPT cyclohydrolase {ECO:0000255|HAMAP-Rule:MF_00486};
GN Name=mch {ECO:0000255|HAMAP-Rule:MF_00486}; OrderedLocusNames=Msm_1723;
OS Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS).
OC Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC Methanobacteriales; Methanobacteriaceae; Methanobrevibacter.
OX NCBI_TaxID=420247;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35061 / DSM 861 / OCM 144 / PS;
RX PubMed=17563350; DOI=10.1073/pnas.0704189104;
RA Samuel B.S., Hansen E.E., Manchester J.K., Coutinho P.M., Henrissat B.,
RA Fulton R., Latreille P., Kim K., Wilson R.K., Gordon J.I.;
RT "Genomic and metabolic adaptations of Methanobrevibacter smithii to the
RT human gut.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:10643-10648(2007).
CC -!- FUNCTION: Catalyzes the reversible interconversion of 5-formyl-H(4)MPT
CC to methenyl-H(4)MPT(+). {ECO:0000255|HAMAP-Rule:MF_00486}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = H(+) +
CC N(5)-formyl-5,6,7,8-tetrahydromethanopterin; Xref=Rhea:RHEA:19053,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58018,
CC ChEBI:CHEBI:58337; EC=3.5.4.27; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_00486};
CC -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); 5,10-
CC methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 3/3.
CC {ECO:0000255|HAMAP-Rule:MF_00486}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00486}.
CC -!- SIMILARITY: Belongs to the MCH family. {ECO:0000255|HAMAP-
CC Rule:MF_00486}.
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DR EMBL; CP000678; ABQ87928.1; -; Genomic_DNA.
DR RefSeq; WP_004035167.1; NC_009515.1.
DR AlphaFoldDB; A5UP00; -.
DR SMR; A5UP00; -.
DR STRING; 420247.Msm_1723; -.
DR PRIDE; A5UP00; -.
DR EnsemblBacteria; ABQ87928; ABQ87928; Msm_1723.
DR GeneID; 5216913; -.
DR KEGG; msi:Msm_1723; -.
DR PATRIC; fig|420247.28.peg.1712; -.
DR eggNOG; arCOG02675; Archaea.
DR HOGENOM; CLU_876031_0_0_2; -.
DR OMA; DKGMFAP; -.
DR UniPathway; UPA00640; UER00694.
DR Proteomes; UP000001992; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0018759; F:methenyltetrahydromethanopterin cyclohydrolase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019386; P:methanogenesis, from carbon dioxide; IEA:UniProtKB-UniPathway.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd00545; MCH; 1.
DR HAMAP; MF_00486; McH; 1.
DR InterPro; IPR003209; METHMP_CycHdrlase.
DR Pfam; PF02289; MCH; 1.
DR TIGRFAMs; TIGR03120; one_C_mch; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Hydrolase; Methanogenesis; One-carbon metabolism.
FT CHAIN 1..323
FT /note="Methenyltetrahydromethanopterin cyclohydrolase"
FT /id="PRO_1000014404"
SQ SEQUENCE 323 AA; 34419 MW; 6611D3E1460F1674 CRC64;
MVSVNLEAKK TVDVMIEKQD ELNIAVSQLS NGATIIDCGV NVDGSFKAGE LYTKVCLGGL
ADVGISIPGD LSEKFALPSV KIKTDSPAIS TLGSQKAGWS VSVGDFFALG SGPARAICKK
PAETYEEIGY EDTEADLAIL TLEADVLPGE DVAQYIADEC NVDVKDVYLL VAPTSSLVGS
IQISGRVVEN GTYKMLEAIK FDVTKVKHAA GIAPIAPIDP DGLKAMGKTN DAVLFGGRTY
YYVESDENDD IADVAAKLPS SAADGYGKPF FDVFKEAEFD FYKIDKGMFA PAEVVINDLT
TGKIYKEGYV NVDLLKKSFG VDN
