ID   MCH_METS4               Reviewed;         324 AA.
AC   B0UF36;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Methenyltetrahydromethanopterin cyclohydrolase {ECO:0000255|HAMAP-Rule:MF_00486};
DE            EC=3.5.4.27 {ECO:0000255|HAMAP-Rule:MF_00486};
DE   AltName: Full=Methenyl-H4MPT cyclohydrolase {ECO:0000255|HAMAP-Rule:MF_00486};
GN   Name=mch {ECO:0000255|HAMAP-Rule:MF_00486}; OrderedLocusNames=M446_5780;
OS   Methylobacterium sp. (strain 4-46).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Methylobacteriaceae; Methylobacterium.
OX   NCBI_TaxID=426117;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=4-46;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C.,
RA   Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Ivanova N., Marx C.J., Richardson P.;
RT   "Complete sequence of chromosome of Methylobacterium sp. 4-46.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl-
CC       H(4)MPT. {ECO:0000255|HAMAP-Rule:MF_00486}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = H(+) +
CC         N(5)-formyl-5,6,7,8-tetrahydromethanopterin; Xref=Rhea:RHEA:19053,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58018,
CC         ChEBI:CHEBI:58337; EC=3.5.4.27; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00486};
CC   -!- PATHWAY: One-carbon metabolism; formaldehyde degradation; formate from
CC       formaldehyde (H(4)MPT route): step 3/5. {ECO:0000255|HAMAP-
CC       Rule:MF_00486}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00486}.
CC   -!- SIMILARITY: Belongs to the MCH family. {ECO:0000255|HAMAP-
CC       Rule:MF_00486}.
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DR   EMBL; CP000943; ACA20068.1; -; Genomic_DNA.
DR   RefSeq; WP_012335446.1; NC_010511.1.
DR   AlphaFoldDB; B0UF36; -.
DR   SMR; B0UF36; -.
DR   STRING; 426117.M446_5780; -.
DR   EnsemblBacteria; ACA20068; ACA20068; M446_5780.
DR   KEGG; met:M446_5780; -.
DR   eggNOG; COG3252; Bacteria.
DR   HOGENOM; CLU_876031_0_0_5; -.
DR   OMA; DKGMFAP; -.
DR   OrthoDB; 1691428at2; -.
DR   UniPathway; UPA00562; UER00703.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0018759; F:methenyltetrahydromethanopterin cyclohydrolase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046294; P:formaldehyde catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd00545; MCH; 1.
DR   HAMAP; MF_00486; McH; 1.
DR   InterPro; IPR003209; METHMP_CycHdrlase.
DR   Pfam; PF02289; MCH; 1.
DR   TIGRFAMs; TIGR03120; one_C_mch; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Hydrolase; One-carbon metabolism.
FT   CHAIN           1..324
FT                   /note="Methenyltetrahydromethanopterin cyclohydrolase"
FT                   /id="PRO_1000191113"
SQ   SEQUENCE   324 AA;  33203 MW;  6DF5FD077240720F CRC64;
     MSSTTVRPSV NALATPLVEA LVADAAKLRL SVSAKSGEAR LVDAGAQARG SIEAGRRIAE
     ICLGGLGTVT IAPAGPVAAW PVTVTVHSAD PVLACLGSQY AGWSLADEGG SSGFFALGSG
     PGRAAAAAEH LFEELHYRDH AAQIALVLES ASAPPASVVA KVAEAAGVTP DAVTFIYAPT
     QSLAGATQVV ARVLEVALHK AHSVGFDLAK VVDGIGAAPL SPPHPDFIQA MGRTNDAIIY
     GGRVQLFVEA DDAEARGLAE ALPSTTSRDH GAPFAEIFAR FNGDFYAIDK HLFSPAEVVV
     TSLLSGTSHR AGRLVPELVE RSFA