MCH_METTH
ID MCH_METTH Reviewed; 320 AA.
AC O26867;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 25-MAY-2022, entry version 124.
DE RecName: Full=Methenyltetrahydromethanopterin cyclohydrolase;
DE EC=3.5.4.27;
DE AltName: Full=Methenyl-H4MPT cyclohydrolase;
GN Name=mch; OrderedLocusNames=MTH_773;
OS Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM
OS 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum).
OC Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX NCBI_TaxID=187420;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H;
RX PubMed=9371463; DOI=10.1128/jb.179.22.7135-7155.1997;
RA Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D.,
RA Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R.,
RA Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D.,
RA Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A.,
RA Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J.,
RA Reeve J.N.;
RT "Complete genome sequence of Methanobacterium thermoautotrophicum deltaH:
RT functional analysis and comparative genomics.";
RL J. Bacteriol. 179:7135-7155(1997).
CC -!- FUNCTION: Catalyzes the reversible interconversion of 5-formyl-H(4)MPT
CC to methenyl-H(4)MPT(+). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = H(+) +
CC N(5)-formyl-5,6,7,8-tetrahydromethanopterin; Xref=Rhea:RHEA:19053,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58018,
CC ChEBI:CHEBI:58337; EC=3.5.4.27;
CC -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); 5,10-
CC methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 3/3.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MCH family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE000666; AAB85276.1; -; Genomic_DNA.
DR PIR; D69203; D69203.
DR RefSeq; WP_010876411.1; NC_000916.1.
DR AlphaFoldDB; O26867; -.
DR SMR; O26867; -.
DR STRING; 187420.MTH_773; -.
DR EnsemblBacteria; AAB85276; AAB85276; MTH_773.
DR GeneID; 1471181; -.
DR KEGG; mth:MTH_773; -.
DR PATRIC; fig|187420.15.peg.761; -.
DR HOGENOM; CLU_876031_0_0_2; -.
DR OMA; DKGMFAP; -.
DR UniPathway; UPA00640; UER00694.
DR Proteomes; UP000005223; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0018759; F:methenyltetrahydromethanopterin cyclohydrolase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019386; P:methanogenesis, from carbon dioxide; IEA:UniProtKB-UniPathway.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd00545; MCH; 1.
DR HAMAP; MF_00486; McH; 1.
DR InterPro; IPR003209; METHMP_CycHdrlase.
DR Pfam; PF02289; MCH; 1.
DR TIGRFAMs; TIGR03120; one_C_mch; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Hydrolase; Methanogenesis; One-carbon metabolism;
KW Reference proteome.
FT CHAIN 1..320
FT /note="Methenyltetrahydromethanopterin cyclohydrolase"
FT /id="PRO_0000140884"
SQ SEQUENCE 320 AA; 34319 MW; C10CE738C675AA02 CRC64;
MVSVNLEAKK IVDRMIEKAD DLKIKVDKLE NGSTVIDCGV NVDGSIKAGE LYTGVCLGGL
ADVGISIPGD LSERFALPSV KIKTDFPAIS TLGAQKAGWS VSVGDFFALG SGPARALSLK
PAETYEEIGY QDEADVAILT LEADKLPGED VTDMIAEECD VAAENVYVLV APTSSLVGSI
QISGRVVENG TYKMLEALHF DVNKVKYAAG IAPIAPVDPD SLKAMGKTND AVLFGGRTYY
YIESEEGDDI KSLAENLPSS ASEGYGKPFY DVFREADYDF YKIDKGMFAP AEVVINDLRT
GDVFRAGFVN EELLMKSFGL
