ID   MCH_METTM               Reviewed;         320 AA.
AC   P51616; D9PX14;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   25-MAY-2022, entry version 110.
DE   RecName: Full=Methenyltetrahydromethanopterin cyclohydrolase;
DE            EC=3.5.4.27;
DE   AltName: Full=Methenyl-H4MPT cyclohydrolase;
GN   Name=mch; OrderedLocusNames=MTBMA_c11690;
OS   Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM
OS   14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium
OS   thermoautotrophicum).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=79929;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 2-30; 85-96;
RP   195-204; 208-223 AND 252-282.
RC   STRAIN=ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 /
RC   Marburg;
RX   PubMed=8617278; DOI=10.1111/j.1432-1033.1996.00294.x;
RA   Vaupel M., Dietz H., Linder D., Thauer R.K.;
RT   "Primary structure of cyclohydrolase (Mch) from Methanobacterium
RT   thermoautotrophicum (strain Marburg) and functional expression of the mch
RT   gene in Escherichia coli.";
RL   Eur. J. Biochem. 236:294-300(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 /
RC   Marburg;
RX   PubMed=20802048; DOI=10.1128/jb.00844-10;
RA   Liesegang H., Kaster A.K., Wiezer A., Goenrich M., Wollherr A., Seedorf H.,
RA   Gottschalk G., Thauer R.K.;
RT   "Complete genome sequence of Methanothermobacter marburgensis, a
RT   methanoarchaeon model organism.";
RL   J. Bacteriol. 192:5850-5851(2010).
CC   -!- FUNCTION: Catalyzes the reversible interconversion of 5-formyl-H(4)MPT
CC       to methenyl-H(4)MPT(+).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = H(+) +
CC         N(5)-formyl-5,6,7,8-tetrahydromethanopterin; Xref=Rhea:RHEA:19053,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58018,
CC         ChEBI:CHEBI:58337; EC=3.5.4.27;
CC   -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); 5,10-
CC       methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 3/3.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the MCH family. {ECO:0000305}.
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DR   EMBL; X92082; CAA63064.1; -; Genomic_DNA.
DR   EMBL; CP001710; ADL58762.1; -; Genomic_DNA.
DR   PIR; S62193; S62193.
DR   RefSeq; WP_013295984.1; NC_014408.1.
DR   AlphaFoldDB; P51616; -.
DR   SMR; P51616; -.
DR   STRING; 79929.MTBMA_c11690; -.
DR   EnsemblBacteria; ADL58762; ADL58762; MTBMA_c11690.
DR   GeneID; 9704877; -.
DR   KEGG; mmg:MTBMA_c11690; -.
DR   PATRIC; fig|79929.8.peg.1138; -.
DR   HOGENOM; CLU_876031_0_0_2; -.
DR   OMA; DKGMFAP; -.
DR   OrthoDB; 31274at2157; -.
DR   UniPathway; UPA00640; UER00694.
DR   Proteomes; UP000000345; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0018537; F:coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity; IDA:MENGO.
DR   GO; GO:0018759; F:methenyltetrahydromethanopterin cyclohydrolase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019386; P:methanogenesis, from carbon dioxide; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd00545; MCH; 1.
DR   HAMAP; MF_00486; McH; 1.
DR   InterPro; IPR003209; METHMP_CycHdrlase.
DR   Pfam; PF02289; MCH; 1.
DR   TIGRFAMs; TIGR03120; one_C_mch; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Direct protein sequencing; Hydrolase; Methanogenesis;
KW   One-carbon metabolism.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:8617278"
FT   CHAIN           2..320
FT                   /note="Methenyltetrahydromethanopterin cyclohydrolase"
FT                   /id="PRO_0000140885"
SQ   SEQUENCE   320 AA;  34230 MW;  9228D33D5951A4B1 CRC64;
     MVSVNIEAKK IVDRMIEGAD DLKISVDKLE NGSTVIDCGV NVDGSIKAGE LYTAVCLGGL
     ADVGISIPGD LSERFALPSV KIKTDFPAIS TLGAQKAGWS VSVGDFFALG SGPARALALK
     PAETYEEIGY QDEADIAVLT LEADKLPGED VTDKIAEECD VSPENVYVLV APTSSLVGSI
     QISGRVVENG TYKMLEALHF DVNKVKYAAG IAPIAPVDPD SLKAMGKTND AVLFGGRTYY
     YIESEEGDDI KSLAENLPSS ASEGYGKPFY DVFKEADYDF YKIDKGMFAP AEVVINDLRT
     GEVFRAGFVN EELLMKSFGL