MCH_METVS
ID MCH_METVS Reviewed; 323 AA.
AC A6UPJ2;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 1.
DT 25-MAY-2022, entry version 70.
DE RecName: Full=Methenyltetrahydromethanopterin cyclohydrolase {ECO:0000255|HAMAP-Rule:MF_00486};
DE EC=3.5.4.27 {ECO:0000255|HAMAP-Rule:MF_00486};
DE AltName: Full=Methenyl-H4MPT cyclohydrolase {ECO:0000255|HAMAP-Rule:MF_00486};
GN Name=mch {ECO:0000255|HAMAP-Rule:MF_00486}; OrderedLocusNames=Mevan_0507;
OS Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148
OS / SB).
OC Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC Methanococcaceae; Methanococcus.
OX NCBI_TaxID=406327;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Anderson I.,
RA Sieprawska-Lupa M., Whitman W.B., Richardson P.;
RT "Complete sequence of Methanococcus vannielii SB.";
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the reversible interconversion of 5-formyl-H(4)MPT
CC to methenyl-H(4)MPT(+). {ECO:0000255|HAMAP-Rule:MF_00486}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = H(+) +
CC N(5)-formyl-5,6,7,8-tetrahydromethanopterin; Xref=Rhea:RHEA:19053,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58018,
CC ChEBI:CHEBI:58337; EC=3.5.4.27; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_00486};
CC -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); 5,10-
CC methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 3/3.
CC {ECO:0000255|HAMAP-Rule:MF_00486}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00486}.
CC -!- SIMILARITY: Belongs to the MCH family. {ECO:0000255|HAMAP-
CC Rule:MF_00486}.
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DR EMBL; CP000742; ABR54414.1; -; Genomic_DNA.
DR RefSeq; WP_011972317.1; NC_009634.1.
DR AlphaFoldDB; A6UPJ2; -.
DR SMR; A6UPJ2; -.
DR STRING; 406327.Mevan_0507; -.
DR EnsemblBacteria; ABR54414; ABR54414; Mevan_0507.
DR GeneID; 5325664; -.
DR KEGG; mvn:Mevan_0507; -.
DR eggNOG; arCOG02675; Archaea.
DR HOGENOM; CLU_876031_0_0_2; -.
DR OMA; DKGMFAP; -.
DR OrthoDB; 31274at2157; -.
DR UniPathway; UPA00640; UER00694.
DR Proteomes; UP000001107; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0018759; F:methenyltetrahydromethanopterin cyclohydrolase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019386; P:methanogenesis, from carbon dioxide; IEA:UniProtKB-UniPathway.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd00545; MCH; 1.
DR HAMAP; MF_00486; McH; 1.
DR InterPro; IPR003209; METHMP_CycHdrlase.
DR Pfam; PF02289; MCH; 1.
DR TIGRFAMs; TIGR03120; one_C_mch; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Hydrolase; Methanogenesis; One-carbon metabolism.
FT CHAIN 1..323
FT /note="Methenyltetrahydromethanopterin cyclohydrolase"
FT /id="PRO_1000014405"
SQ SEQUENCE 323 AA; 34734 MW; 0A752489F006A274 CRC64;
MVSVNLSSLP IVLDMINRND DLNIQVIKLE NGATVLDCGV NVTGSFEAGK LFTKICLGGL
AHVGISISGT LDNKMVLPCV KVKTSHPAVA TLGAQKAGWS VSVGKYFAMG SGPARALAMM
PKVTYEEIEY RDDADVAILC LEASKLPDEK VADYVAQKCG VDVSKVYLLV APTASIVGAV
QISGRVVENG TYKMLEALHF DVRKVKLAAG IAPIAPIIGD DLKMMGATND MVLYGGRTFY
YIKSDEGDDI EALCKSLPSC SAQTYGKPFL EVFKEANYDF YKIDKGMFAP AVVTINDLRT
GKLVTHGNTN IDVLKKSLKY TEI
