ID   MCH_OREMO               Reviewed;         136 AA.
AC   P49794;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 50.
DE   RecName: Full=Pro-MCH;
DE   Contains:
DE     RecName: Full=Melanin-concentrating hormone;
DE              Short=MCH;
DE   Flags: Precursor;
GN   Name=mch;
OS   Oreochromis mossambicus (Mozambique tilapia) (Tilapia mossambica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8127;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Hypothalamus;
RA   Groneveld D., Hut M.J., Balm P.H.M., Martens G.J.M., Wendelaar Bonga S.E.;
RT   "Cloning and sequence analysis of hypothalamus cDNA encoding tilapia
RT   melanin-concentrating hormone.";
RL   Fish Physiol. Biochem. 11:117-124(1993).
CC   -!- FUNCTION: Plays a role in skin pigmentation by antagonizing the action
CC       of melanotropin alpha. Induces melanin concentration within the
CC       melanophores. May participate in the control of the hypothalamo-
CC       pituitary adrenal gland axis by inhibiting the release of ACTH.
CC   -!- SIMILARITY: Belongs to the melanin-concentrating hormone family.
CC       {ECO:0000305}.
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DR   EMBL; X81144; CAA57050.1; -; mRNA.
DR   AlphaFoldDB; P49794; -.
DR   BMRB; P49794; -.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0030354; F:melanin-concentrating hormone activity; IEA:InterPro.
DR   GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR005456; Prepro-melanin_conc_hormone.
DR   PANTHER; PTHR12091; PTHR12091; 1.
DR   Pfam; PF05824; Pro-MCH; 1.
DR   PRINTS; PR01641; PROMCHFAMILY.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond; Hormone; Neuropeptide;
KW   Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..136
FT                   /note="Pro-MCH"
FT                   /id="PRO_0000019141"
FT   PEPTIDE         119..136
FT                   /note="Melanin-concentrating hormone"
FT                   /id="PRO_0000019142"
FT   DISULFID        124..133
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   136 AA;  15410 MW;  91EA3AE3B91500DD CRC64;
     MRQSRLSIIF AAALFFKCYA LTVALPMAKA EDGSLEKDAF TSLLNDEATE NSLGDAELSS
     MTKSRAPRVI VIAADANLWR DLRVLHNGLP LYKRRVDENN QVVEHKDVGQ DLTIPILRRD
     TMRCMVGRVY RPCWEV