ID   MCH_RHOBA               Reviewed;         333 AA.
AC   Q7UPS1;
DT   21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Methenyltetrahydromethanopterin cyclohydrolase;
DE            EC=3.5.4.27;
DE   AltName: Full=Methenyl-H4MPT cyclohydrolase;
GN   Name=mch; OrderedLocusNames=RB6759;
OS   Rhodopirellula baltica (strain DSM 10527 / NCIMB 13988 / SH1).
OC   Bacteria; Planctomycetes; Planctomycetia; Pirellulales; Pirellulaceae;
OC   Rhodopirellula.
OX   NCBI_TaxID=243090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 10527 / NCIMB 13988 / SH1;
RX   PubMed=12835416; DOI=10.1073/pnas.1431443100;
RA   Gloeckner F.O., Kube M., Bauer M., Teeling H., Lombardot T., Ludwig W.,
RA   Gade D., Beck A., Borzym K., Heitmann K., Rabus R., Schlesner H., Amann R.,
RA   Reinhardt R.;
RT   "Complete genome sequence of the marine planctomycete Pirellula sp. strain
RT   1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:8298-8303(2003).
CC   -!- FUNCTION: Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl-
CC       H(4)MPT. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = H(+) +
CC         N(5)-formyl-5,6,7,8-tetrahydromethanopterin; Xref=Rhea:RHEA:19053,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58018,
CC         ChEBI:CHEBI:58337; EC=3.5.4.27;
CC   -!- PATHWAY: One-carbon metabolism; formaldehyde degradation; formate from
CC       formaldehyde (H(4)MPT route): step 3/5.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MCH family. {ECO:0000305}.
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DR   EMBL; BX294144; CAD74990.1; -; Genomic_DNA.
DR   RefSeq; NP_867444.1; NC_005027.1.
DR   RefSeq; WP_011121084.1; NC_005027.1.
DR   AlphaFoldDB; Q7UPS1; -.
DR   SMR; Q7UPS1; -.
DR   STRING; 243090.RB6759; -.
DR   EnsemblBacteria; CAD74990; CAD74990; RB6759.
DR   KEGG; rba:RB6759; -.
DR   PATRIC; fig|243090.15.peg.3279; -.
DR   eggNOG; COG3252; Bacteria.
DR   HOGENOM; CLU_876031_0_0_0; -.
DR   InParanoid; Q7UPS1; -.
DR   OMA; DKGMFAP; -.
DR   OrthoDB; 1691428at2; -.
DR   UniPathway; UPA00562; UER00703.
DR   Proteomes; UP000001025; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0018759; F:methenyltetrahydromethanopterin cyclohydrolase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046294; P:formaldehyde catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00486; McH; 1.
DR   InterPro; IPR003209; METHMP_CycHdrlase.
DR   Pfam; PF02289; MCH; 1.
DR   TIGRFAMs; TIGR03120; one_C_mch; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Hydrolase; One-carbon metabolism; Reference proteome.
FT   CHAIN           1..333
FT                   /note="Methenyltetrahydromethanopterin cyclohydrolase"
FT                   /id="PRO_0000140897"
SQ   SEQUENCE   333 AA;  35408 MW;  BE1E5BD033A92A89 CRC64;
     MKSATPDDLP RTGVEPDLSR SASECFESLW NGAIGMRSLP LTIAGARVLD AGVTCSGSLE
     AGLGLARLCL GDLANVRYVP ATADDLVGLS VTIQTDHPVL SCLGGQYAGW PVSVADYFAM
     ASGPMRCLRG KEAMLEQLHL SRQATDDDFA VGVLESDTLP GEDVIEAMAD ECGVDPSRLC
     LAVAPSTSIA GSAQVVSRSV ETALHKLHAL EFDVTRVVSA HGDAPLPPPA KKGDTIGGIG
     RTNDAMLYGA RVTLWVDAED DAIDSVASKV PSQSSDDHGR PFAEIFKQYE YDFYQVDPML
     FSPAVVTIHS LQSGRTWRHG QISIDVMRKS FGL