ID   MCIN_BOVIN              Reviewed;         374 AA.
AC   G3N1S4;
DT   21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT   16-NOV-2011, sequence version 1.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=Multicilin;
DE   AltName: Full=Multiciliate differentiation and DNA synthesis-associated cell cycle protein;
DE            Short=McIdas protein;
DE   AltName: Full=Protein Idas;
GN   Name=MCIDAS; Synonyms=IDAS, MCI, MCIN;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford;
RX   PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA   Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., Puiu D.,
RA   Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., Marcais G.,
RA   Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT   "A whole-genome assembly of the domestic cow, Bos taurus.";
RL   Genome Biol. 10:R42.01-R42.10(2009).
CC   -!- FUNCTION: Transcription regulator specifically required for
CC       multiciliate cell differentiation. Acts in a multiprotein complex
CC       containing E2F4 and E2F5 that binds and activates genes required for
CC       centriole biogenesis. Required for the deuterosome-mediated acentriolar
CC       pathway. Plays a role in mitotic cell cycle progression by promoting
CC       cell cycle exit. Modulates GMNN activity by reducing its affinity for
CC       CDT1. {ECO:0000250|UniProtKB:D6RGH6, ECO:0000250|UniProtKB:Q08B36}.
CC   -!- SUBUNIT: Heterodimer (via coiled-coil domain) with GMNN (via coiled-
CC       coil domain); targets GMNN to the nucleus. Can form homodimers (in
CC       vitro, via coiled-coil domain), but these are much less stable than the
CC       heterodimer formed with GMNN. {ECO:0000250|UniProtKB:D6RGH6}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:D6RGH6}.
CC       Note=Excluded from the nucleolus. {ECO:0000250|UniProtKB:D6RGH6}.
CC   -!- SIMILARITY: Belongs to the geminin family. {ECO:0000305}.
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DR   EMBL; DAAA02050347; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_002696376.1; XM_002696330.4.
DR   RefSeq; XP_003585159.1; XM_003585111.4.
DR   AlphaFoldDB; G3N1S4; -.
DR   SMR; G3N1S4; -.
DR   STRING; 9913.ENSBTAP00000055827; -.
DR   PaxDb; G3N1S4; -.
DR   Ensembl; ENSBTAT00000064796; ENSBTAP00000055827; ENSBTAG00000047087.
DR   GeneID; 100301340; -.
DR   KEGG; bta:100301340; -.
DR   CTD; 345643; -.
DR   VEuPathDB; HostDB:ENSBTAG00000047087; -.
DR   VGNC; VGNC:31306; MCIDAS.
DR   eggNOG; ENOG502R4B5; Eukaryota.
DR   GeneTree; ENSGT00940000153270; -.
DR   HOGENOM; CLU_063884_0_0_1; -.
DR   InParanoid; G3N1S4; -.
DR   OMA; ITQSRDC; -.
DR   OrthoDB; 935155at2759; -.
DR   TreeFam; TF101171; -.
DR   Proteomes; UP000009136; Chromosome 20.
DR   Bgee; ENSBTAG00000047087; Expressed in olfactory segment of nasal mucosa and 13 other tissues.
DR   GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0003713; F:transcription coactivator activity; IEA:InterPro.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0098534; P:centriole assembly; ISS:UniProtKB.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:0044458; P:motile cilium assembly; ISS:UniProtKB.
DR   GO; GO:1903251; P:multi-ciliated epithelial cell differentiation; ISS:UniProtKB.
DR   GO; GO:0045786; P:negative regulation of cell cycle; IBA:GO_Central.
DR   GO; GO:0008156; P:negative regulation of DNA replication; IBA:GO_Central.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:1902017; P:regulation of cilium assembly; ISS:UniProtKB.
DR   GO; GO:0030174; P:regulation of DNA-templated DNA replication initiation; IEA:Ensembl.
DR   GO; GO:0007346; P:regulation of mitotic cell cycle; IEA:Ensembl.
DR   InterPro; IPR022786; Geminin/Multicilin.
DR   InterPro; IPR029699; Multicilin/Idas.
DR   PANTHER; PTHR13372:SF3; PTHR13372:SF3; 1.
DR   Pfam; PF07412; Geminin; 1.
PE   3: Inferred from homology;
KW   Activator; Cell cycle; Cilium biogenesis/degradation; Coiled coil; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..374
FT                   /note="Multicilin"
FT                   /id="PRO_0000416279"
FT   REGION          18..72
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          84..105
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          284..306
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          168..216
FT                   /evidence="ECO:0000250|UniProtKB:D6RGH6"
FT   COMPBIAS        28..42
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        284..298
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   374 AA;  40621 MW;  F240505888688221 CRC64;
     MQECGATAAG RRAFDSICPN RMLDPRGRPI SKPGKPERKF APPRKFFPGS SGCNRVSVYE
     DPPDAETPAL PALTTIDLQD LADCSSFLGS DPPPGGDSAA SQSHSLQTAA DFDLQDFRDT
     VDNLIADSSS LMSPSLAGGD LPFSPSDVLP FGPCLSPPLS PPEVPPPEQY WKEVADQNQR
     ALGDALIENN QLHATLTQKQ EEIASLKERN LQLKELASRT RHLASVLDKL MITHSRDPGA
     AAEPFLLKAT AKRSLEELFS AAGQDCAEVD AVLREISERC DEALQSRDPK RLRLQPEPQS
     LDRRPGNLHG AFPGLRTDCS LSTLNLSHSE LEEGGSFSTP IRSHSTIRTL AFPQGNAFTI
     RTANGGYKFR WIPS