ID   MCIN_XENTR              Reviewed;         376 AA.
AC   F7BHS0;
DT   21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2012, sequence version 2.
DT   03-AUG-2022, entry version 48.
DE   RecName: Full=Multicilin;
DE   AltName: Full=Multiciliate differentiation and DNA synthesis-associated cell cycle protein;
DE            Short=McIdas protein;
DE   AltName: Full=Protein Idas;
GN   Name=mcidas; Synonyms=idas, mci, mcin;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA   Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA   Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA   Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA   Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA   Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA   Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA   Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
CC   -!- FUNCTION: Transcription regulator specifically required for
CC       multiciliate cell differentiation. Acts in a multiprotein complex
CC       containing e2f4 and e2f5 that binds and activate genes required for
CC       centriole biogenesis. Activates genes required for centriole assembly
CC       (plk4, cep152) and genes specifically required for motile cilia
CC       formation (foxj1). Also promotes the deuterosome pathway of centriole
CC       biogenesis by activating expression of deup1, but not its paralog
CC       cep63. {ECO:0000250|UniProtKB:Q08B36}.
CC   -!- SUBUNIT: Component of the EDM complex, at least composed of e2f4, e2f5,
CC       mcidas and tfdp1. {ECO:0000250|UniProtKB:Q08B36}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q08B36}.
CC   -!- DOMAIN: The TIRT domain mediates interaction with e2f4 and tfdp1.
CC       {ECO:0000250|UniProtKB:Q08B36}.
CC   -!- SIMILARITY: Belongs to the geminin family. {ECO:0000305}.
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DR   EMBL; AAMC01110993; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_002941156.1; XM_002941110.4.
DR   AlphaFoldDB; F7BHS0; -.
DR   SMR; F7BHS0; -.
DR   STRING; 8364.ENSXETP00000058983; -.
DR   PaxDb; F7BHS0; -.
DR   Ensembl; ENSXETT00000061414; ENSXETP00000058983; ENSXETG00000033274.
DR   GeneID; 100496713; -.
DR   KEGG; xtr:100496713; -.
DR   CTD; 345643; -.
DR   Xenbase; XB-GENE-22041448; mcidas.
DR   eggNOG; ENOG502R4B5; Eukaryota.
DR   HOGENOM; CLU_063884_0_0_1; -.
DR   InParanoid; F7BHS0; -.
DR   OrthoDB; 935155at2759; -.
DR   PhylomeDB; F7BHS0; -.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000033274; Expressed in gastrula and 2 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003713; F:transcription coactivator activity; IEA:InterPro.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0098534; P:centriole assembly; ISS:UniProtKB.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:0044458; P:motile cilium assembly; ISS:UniProtKB.
DR   GO; GO:1903251; P:multi-ciliated epithelial cell differentiation; ISS:UniProtKB.
DR   GO; GO:0045786; P:negative regulation of cell cycle; IBA:GO_Central.
DR   GO; GO:0008156; P:negative regulation of DNA replication; IBA:GO_Central.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:1902017; P:regulation of cilium assembly; ISS:UniProtKB.
DR   GO; GO:0007346; P:regulation of mitotic cell cycle; IEA:InterPro.
DR   InterPro; IPR022786; Geminin/Multicilin.
DR   InterPro; IPR029699; Multicilin/Idas.
DR   PANTHER; PTHR13372:SF3; PTHR13372:SF3; 1.
DR   Pfam; PF07412; Geminin; 1.
PE   3: Inferred from homology;
KW   Activator; Cell cycle; Cilium biogenesis/degradation; Coiled coil; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..376
FT                   /note="Multicilin"
FT                   /id="PRO_0000416281"
FT   REGION          230..261
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          331..376
FT                   /note="TIRT domain"
FT                   /evidence="ECO:0000250|UniProtKB:Q08B36"
FT   COILED          165..213
FT                   /evidence="ECO:0000250|UniProtKB:D6RGH6"
SQ   SEQUENCE   376 AA;  41817 MW;  FC56E6AF2E736621 CRC64;
     MQNRRKAFDK LCPNTMPDLS SRMGKRQSKT EKKLHKNIFT HTGPVTIYVD PPSSVDSAAL
     ATIDWQDLAD CNSVIQQDAA GGALTEQQQQ GHCLPGESDF DLQEFRDAVD QFIADQPSLM
     QPGLGSSGFQ LPCNGSVFEP CMTDTLQPQP DHLLPISVQS IPSTEQYWRD VADHNQKALG
     DALVENNQLQ VSLTEKQEEI ASLKEKNIQL NELANQAKHL ASVLDKLMKE RPKHSSGATQ
     GRLPVKRSLE DFYPQSNEPD STQVDEILRE ISKKCNIALM GNELSESKRP RLEPMDTMGW
     QEEGITKIKM CGAFNGLKTS TGLNSVNLGE TELEEDVSFR TSIKEHSTIR TLAFPQGNAF
     TIRTAAGGYK FRWVPN