MCL1B_DANRE
ID MCL1B_DANRE Reviewed; 404 AA.
AC Q1LWL8;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Protein L-Myc-1b;
GN Name=mycl1b {ECO:0000312|ZFIN:ZDB-GENE-030131-5561};
GN ORFNames=si:ch211-194e15.2, zgc:152988;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000312|EMBL:CAK04288.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=SJD;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC protein. Binds DNA as a heterodimer with max (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P12524,
CC ECO:0000255|PROSITE-ProRule:PRU00981}.
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DR EMBL; BX547927; CAK04288.1; -; Genomic_DNA.
DR EMBL; BC124204; AAI24205.1; -; mRNA.
DR RefSeq; NP_001038607.1; NM_001045142.1.
DR AlphaFoldDB; Q1LWL8; -.
DR SMR; Q1LWL8; -.
DR STRING; 7955.ENSDARP00000094300; -.
DR PaxDb; Q1LWL8; -.
DR Ensembl; ENSDART00000103524; ENSDARP00000094300; ENSDARG00000034956.
DR Ensembl; ENSDART00000184875; ENSDARP00000150895; ENSDARG00000034956.
DR Ensembl; ENSDART00000187012; ENSDARP00000144989; ENSDARG00000110185.
DR GeneID; 567762; -.
DR KEGG; dre:567762; -.
DR CTD; 567762; -.
DR ZFIN; ZDB-GENE-030131-5561; myclb.
DR eggNOG; ENOG502QWSU; Eukaryota.
DR GeneTree; ENSGT00940000158613; -.
DR HOGENOM; CLU_052560_0_0_1; -.
DR InParanoid; Q1LWL8; -.
DR OMA; CHPRPVS; -.
DR OrthoDB; 877891at2759; -.
DR PhylomeDB; Q1LWL8; -.
DR TreeFam; TF106001; -.
DR PRO; PR:Q1LWL8; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 19.
DR Bgee; ENSDARG00000034956; Expressed in presomitic mesoderm and 28 other tissues.
DR ExpressionAtlas; Q1LWL8; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0032502; P:developmental process; IEA:UniProt.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR002418; Tscrpt_reg_Myc.
DR InterPro; IPR012682; Tscrpt_reg_Myc_N.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF01056; Myc_N; 2.
DR PIRSF; PIRSF001705; Myc_protein; 1.
DR PRINTS; PR00044; LEUZIPPRMYC.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome.
FT CHAIN 1..404
FT /note="Protein L-Myc-1b"
FT /id="PRO_0000271178"
FT DOMAIN 321..373
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 175..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 238..331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 373..401
FT /note="Leucine-zipper"
FT COMPBIAS 250..264
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 289..315
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..331
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 404 AA; 45646 MW; E7A3485B3649BDF4 CRC64;
MPGISASASR IKKWEMEEYD QYQHYFYDDH NLDEDFFKST APSEDIWKKF ELVPTPPMSP
VRILEGSGPS PGDRLEWVSQ FLGQDDEQEG LCKLNAEETL ENLSSIIIQD CMWSSFSASQ
QLEKVVSERL SCSAQSKLSG KAQCVPADVP ALNSLATDCV DPAAVLTFPL SSSCKKQVSS
GSESRTDSSD DEEIDVVTVE HKQNKSRLVN ARKPVTITVR ADPHDPCMKR FHISIHQQQH
NYAARSPDSY PEEEPPRKKI RQEIVQPRLA STPQTPERKS PLPSPSVPAQ SPTVSASPTH
TSYHLKSQPS SPQSSDCEDT DKRKTHNFLE RKRRNDLRSR FLALRDEIPG LVDCPKTPKV
VILTKATEYL RTLHVSDRQK AQEKKQLKSK QQQLLRRLAE LKRA
