MCM1_CANAL
ID MCM1_CANAL Reviewed; 262 AA.
AC Q5AFP3; A0A1D8PQQ0; Q3MPP3;
DT 28-NOV-2012, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 25-MAY-2022, entry version 110.
DE RecName: Full=Transcription factor of morphogenesis MCM1;
GN Name=MCM1; OrderedLocusNames=CAALFM_C700890CA; ORFNames=CaO19.7025;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [4]
RP INDUCTION.
RX PubMed=11443097; DOI=10.1128/jb.183.15.4614-4625.2001;
RA Srikantha T., Tsai L., Daniels K., Klar A.J., Soll D.R.;
RT "The histone deacetylase genes HDA1 and RPD3 play distinct roles in
RT regulation of high-frequency phenotypic switching in Candida albicans.";
RL J. Bacteriol. 183:4614-4625(2001).
RN [5]
RP FUNCTION.
RX PubMed=12581351; DOI=10.1046/j.1365-2958.2003.03358.x;
RA Rottmann M., Dieter S., Brunner H., Rupp S.;
RT "A screen in Saccharomyces cerevisiae identified CaMCM1, an essential gene
RT in Candida albicans crucial for morphogenesis.";
RL Mol. Microbiol. 47:943-959(2003).
RN [6]
RP FUNCTION, DNA-BINDING, AND INTERACTION WITH AHR1.
RX PubMed=21299649; DOI=10.1111/j.1365-2958.2010.07504.x;
RA Askew C., Sellam A., Epp E., Mallick J., Hogues H., Mullick A., Nantel A.,
RA Whiteway M.;
RT "The zinc cluster transcription factor Ahr1p directs Mcm1p regulation of
RT Candida albicans adhesion.";
RL Mol. Microbiol. 79:940-953(2011).
CC -!- FUNCTION: Transcription factor that is recruited by AHR1 to the
CC promoters of genes involved in biofilm formation, which include several
CC key adhesion genes. Plays an important role in cell adhesion, hyphal
CC growth and virulence. Implicated in the regulation of opaque-phase-
CC specific gene expression. {ECO:0000269|PubMed:12581351,
CC ECO:0000269|PubMed:21299649}.
CC -!- SUBUNIT: Interacts with AHR1. {ECO:0000269|PubMed:21299649}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00251}.
CC -!- INDUCTION: Expression is high in white-phase cells and low in opaque-
CC phase cells. {ECO:0000269|PubMed:11443097}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP017629; AOW30465.1; -; Genomic_DNA.
DR RefSeq; XP_720319.1; XM_715226.1.
DR AlphaFoldDB; Q5AFP3; -.
DR SMR; Q5AFP3; -.
DR BioGRID; 1221144; 2.
DR STRING; 237561.Q5AFP3; -.
DR GeneID; 3638050; -.
DR KEGG; cal:CAALFM_C700890CA; -.
DR CGD; CAL0000194125; MCM1.
DR VEuPathDB; FungiDB:C7_00890C_A; -.
DR eggNOG; KOG0015; Eukaryota.
DR HOGENOM; CLU_063931_0_0_1; -.
DR InParanoid; Q5AFP3; -.
DR OMA; AGHAHHI; -.
DR OrthoDB; 1534637at2759; -.
DR Proteomes; UP000000559; Chromosome 7.
DR GO; GO:0000785; C:chromatin; IDA:CGD.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IDA:CGD.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0030447; P:filamentous growth; IMP:CGD.
DR GO; GO:0044182; P:filamentous growth of a population of unicellular organisms; IMP:CGD.
DR GO; GO:1900461; P:positive regulation of pseudohyphal growth by positive regulation of transcription from RNA polymerase II promoter; IMP:CGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:2000220; P:regulation of pseudohyphal growth; IMP:CGD.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00266; MADS_SRF_like; 1.
DR Gene3D; 3.40.1810.10; -; 1.
DR InterPro; IPR033897; MADS_SRF-like.
DR InterPro; IPR002100; TF_MADSbox.
DR InterPro; IPR036879; TF_MADSbox_sf.
DR Pfam; PF00319; SRF-TF; 1.
DR PRINTS; PR00404; MADSDOMAIN.
DR SMART; SM00432; MADS; 1.
DR SUPFAM; SSF55455; SSF55455; 1.
DR PROSITE; PS50066; MADS_BOX_2; 1.
PE 1: Evidence at protein level;
KW Cell adhesion; DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation; Virulence.
FT CHAIN 1..262
FT /note="Transcription factor of morphogenesis MCM1"
FT /id="PRO_0000420187"
FT DOMAIN 58..118
FT /note="MADS-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00251"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 140..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 148..168
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..262
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 262 AA; 28602 MW; B65C5976BDBFDB08 CRC64;
MAIKEETNEF SQGNEGNSHS TNNNNNSNNS NSNNNADVSA PVDDDDDDDG TSQGKTQKER
RKIEIKFIQE KSRRHITFSK RKAGIMKKAY ELSVLTGTQV LLLVVSETGL VYTFTTPKLQ
PLVTKSEGKN LIQACLNAPE EGLGDDQENQ SDGNTGDSPD QSPAPATNPN VMGAAGHAHH
IQQQQQQQQQ AQQQAQQQMA PMPSHGLPTH YSNPQGAGNP GVPPQQQGQH QPGIPLQGGY
SDQYSYFGNI QNNNIPNQQQ YQ
