MCM5_ORYSI
ID MCM5_ORYSI Reviewed; 729 AA.
AC B8AEH3;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 1.
DT 03-AUG-2022, entry version 79.
DE RecName: Full=DNA replication licensing factor MCM5;
DE EC=3.6.4.12;
DE AltName: Full=Minichromosome maintenance protein 5;
GN Name=MCM5; ORFNames=OsI_09290;
OS Oryza sativa subsp. indica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39946;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. 93-11;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
CC -!- FUNCTION: Probable component of the MCM2-7 complex (MCM complex) that
CC may function as a DNA helicase and which is essential to undergo a
CC single round of replication initiation and elongation per cell cycle in
CC eukaryotic cells. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC -!- SUBUNIT: Component of the minichromosome maintenance (MCM) complex, a
CC heterotetramer composed of MCM2, MCM3, MCM4, MCM5, MCM6 and MCM7.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the MCM family. {ECO:0000305}.
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DR EMBL; CM000127; EEC74176.1; -; Genomic_DNA.
DR AlphaFoldDB; B8AEH3; -.
DR SMR; B8AEH3; -.
DR STRING; 39946.B8AEH3; -.
DR EnsemblPlants; BGIOSGA005432-TA; BGIOSGA005432-PA; BGIOSGA005432.
DR Gramene; BGIOSGA005432-TA; BGIOSGA005432-PA; BGIOSGA005432.
DR HOGENOM; CLU_000995_7_2_1; -.
DR OMA; ITYCKTR; -.
DR Proteomes; UP000007015; Chromosome 2.
DR GO; GO:0000785; C:chromatin; IEA:EnsemblPlants.
DR GO; GO:0005737; C:cytoplasm; IEA:EnsemblPlants.
DR GO; GO:0042555; C:MCM complex; IEA:InterPro.
DR GO; GO:0000347; C:THO complex; IEA:EnsemblPlants.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR Gene3D; 2.40.50.140; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR008048; MCM5.
DR InterPro; IPR018525; MCM_CS.
DR InterPro; IPR001208; MCM_dom.
DR InterPro; IPR041562; MCM_lid.
DR InterPro; IPR027925; MCM_N.
DR InterPro; IPR033762; MCM_OB.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11630; PTHR11630; 1.
DR Pfam; PF00493; MCM; 1.
DR Pfam; PF17855; MCM_lid; 1.
DR Pfam; PF14551; MCM_N; 1.
DR Pfam; PF17207; MCM_OB; 1.
DR PRINTS; PR01657; MCMFAMILY.
DR PRINTS; PR01661; MCMPROTEIN5.
DR SMART; SM00350; MCM; 1.
DR SUPFAM; SSF50249; SSF50249; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00847; MCM_1; 1.
DR PROSITE; PS50051; MCM_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cell cycle; DNA replication; DNA-binding; Helicase; Hydrolase;
KW Nucleotide-binding; Nucleus; Reference proteome.
FT CHAIN 1..729
FT /note="DNA replication licensing factor MCM5"
FT /id="PRO_0000425995"
FT DOMAIN 326..532
FT /note="MCM"
FT MOTIF 508..511
FT /note="Arginine finger"
FT BINDING 376..383
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
SQ SEQUENCE 729 AA; 80362 MW; 65332A3D88DB04BE CRC64;
MSGWDEGAVF YSDQAQFPRG GPGGDPSADL TRHSALRKFK EFLRGFTGPT GDFPYRESLV
HNRDHVTVAI EDLDAFDAEL SDKIRKSPAD YLPLFETAAS EVLASLRSKV AGETGEMEEP
ASGDVQIFLS SKENCLSMRS IGADYMSKLV KIAGITIAAS RVKAKATHVT LLCKNCRSVK
TVPCRPGLGG AIVPRSCDHV PQPGEEPCPL DPWIAVPDKS KYVDLQTLKL QENPEDVPTG
ELPRNMLLSV DRHLVQTIVP GTRLTVIGIY SVYQASANQK GAVGVKQPYI RVVGLEQSRD
ANSNGPSNFT LDEEMEFKEF AQRPDAYVKI CSMIGPSIYG HSDVKKAIAC LLFGGSKKRL
PDGVRLRGDI HVLLLGDPST AKSQFLKFVE KTAPIAVYTS GKGSSAAGLT ASVIRDGSSR
EFYLEGGAMV LADGGVVCID EFDKMRPEDR VAIHEAMEQQ TISIAKAGIT TVLNSRTSVL
AAANPIAGRY DDLKTAQDNI DLQTTILSRF DLIFIVKDVR MYDQDKRIAS HIIKVHASGA
AASSKNTDAS EGENWLKRYI EYCRVTCKPR LSEKAAEMLQ NKYVEIRQKM RQQAHETGRA
AAIPITVRQL EAIIRLSESL AKMRLTSVAT PEHVEEAFRL FNVSTVDAAR SGINEHLNLS
PDIANEIKQA EAQIKRRMGI GSHISERRLI DELNRMGMNE SIVRRALLIM HQRDEVEYKR
ERHVIVRKA
