MCM6_ORYSI
ID MCM6_ORYSI Reviewed; 830 AA.
AC B8AZX3;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 1.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=DNA replication licensing factor MCM6;
DE EC=3.6.4.12;
DE AltName: Full=Minichromosome maintenance protein 6;
GN Name=MCM6; ORFNames=OsI_19080;
OS Oryza sativa subsp. indica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39946;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. 93-11;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
CC -!- FUNCTION: Probable component of the MCM2-7 complex (MCM complex) that
CC may function as a DNA helicase and which is essential to undergo a
CC single round of replication initiation and elongation per cell cycle in
CC eukaryotic cells. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC -!- SUBUNIT: Component of the minichromosome maintenance (MCM) complex, a
CC heterotetramer composed of MCM2, MCM3, MCM4, MCM5, MCM6 and MCM7.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the MCM family. {ECO:0000305}.
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DR EMBL; CM000130; EEC78811.1; -; Genomic_DNA.
DR AlphaFoldDB; B8AZX3; -.
DR SMR; B8AZX3; -.
DR STRING; 39946.B8AZX3; -.
DR EnsemblPlants; BGIOSGA019443-TA; BGIOSGA019443-PA; BGIOSGA019443.
DR Gramene; BGIOSGA019443-TA; BGIOSGA019443-PA; BGIOSGA019443.
DR HOGENOM; CLU_000995_3_2_1; -.
DR OMA; KYYIAQI; -.
DR Proteomes; UP000007015; Chromosome 5.
DR GO; GO:0042555; C:MCM complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR Gene3D; 2.40.50.140; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR008049; MCM6.
DR InterPro; IPR041024; Mcm6_C.
DR InterPro; IPR018525; MCM_CS.
DR InterPro; IPR001208; MCM_dom.
DR InterPro; IPR041562; MCM_lid.
DR InterPro; IPR027925; MCM_N.
DR InterPro; IPR033762; MCM_OB.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11630; PTHR11630; 1.
DR Pfam; PF00493; MCM; 1.
DR Pfam; PF18263; MCM6_C; 1.
DR Pfam; PF17855; MCM_lid; 1.
DR Pfam; PF14551; MCM_N; 1.
DR Pfam; PF17207; MCM_OB; 1.
DR PRINTS; PR01657; MCMFAMILY.
DR PRINTS; PR01662; MCMPROTEIN6.
DR SMART; SM00350; MCM; 1.
DR SUPFAM; SSF50249; SSF50249; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00847; MCM_1; 1.
DR PROSITE; PS50051; MCM_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cell cycle; DNA replication; DNA-binding; Helicase; Hydrolase;
KW Metal-binding; Nucleotide-binding; Nucleus; Reference proteome; Zinc;
KW Zinc-finger.
FT CHAIN 1..830
FT /note="DNA replication licensing factor MCM6"
FT /id="PRO_0000425998"
FT DOMAIN 349..555
FT /note="MCM"
FT ZN_FING 159..186
FT /note="C4-type"
FT /evidence="ECO:0000255"
FT REGION 671..710
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 531..534
FT /note="Arginine finger"
FT BINDING 399..406
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
SQ SEQUENCE 830 AA; 92485 MW; 3722946C3BB8D0F0 CRC64;
MEAFGGFFVD EKAARVENIF LEFLRRFKEA DAAEAFYETE LEAMRSREST TMYVDFAHVM
RFNDVLQKAI SEEYLRFEPY LRNACKRFVM EQRTGENRAP IISDDSPNKD INIAFYNIPM
LKRLRELGTA EIGKLTAVMG VVTRTSEVRP ELLQGTFKCL DCGNVVKNVE QQFKYTEPII
CVNATCQNRS KWALLRQESK FTDWQRVRMQ ETSKEIPAGS LPRSLDVILR HEIVEKARAG
DTVIFTGTVA AVPDVMALTS PGERAECRRE APQRKNGSGV QEGVKGLKSL GVRDLSYRLA
FVANSVQVAD GRREVDIRDR DIDGDDSERQ KFTEEEEDEV VRMRNVPDFF NKIVDSICPT
VFGHQEIKRA ILLMLLGGVH KITHEGINLR GDINVCIVGD PSCAKSQFLK YTAGIVPRSV
YTSGKSSSAA GLTATVAKEP ETGEFCIEAG ALMLADNGIC CIDEFDKMDI KDQVAIHEAM
EQQTISITKA GIQATLNART SILAAANPTG GRYDKSKPLK YNVALPPAIL SRFDLVYIMI
DEPDENTDYH IAHHIVRVHQ KREEALAPAF STAELKRYIA FAKSLKPQLS SEAKKVLVES
YVTLRRGDST PGTRVAYRMT VRQLEALIRL SEAIARSHLE RVVLPAHVRM AVKLLKTSII
SVESSEVDLS DFQDADDGTN VPADNDAGQP TEMDAAPQQD GPENEQAADT GKKKLVITEE
HFQRVTQALV MRLRQHEESV TKDGDGLAGM KQGDLIIWYV EQQNAQGAYS STAEVKEEVK
CIKAIIERLI QRDGHLIVID EGAAPAADDG AARRTSESRI LAVNPNYVID
