ID   MCM6_ORYSJ              Reviewed;         830 AA.
AC   Q6F353; A0A0P0WJU6;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 140.
DE   RecName: Full=DNA replication licensing factor MCM6;
DE            EC=3.6.4.12;
DE   AltName: Full=Minichromosome maintenance protein 6;
DE            Short=OsMCM6;
GN   OrderedLocusNames=Os05g0235800, LOC_Os05g14590;
GN   ORFNames=OJ1384_A02.2, OsJ_17726, OSJNBa0093E24.13;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16261349; DOI=10.1007/s00438-005-0039-y;
RA   Cheng C.-H., Chung M.C., Liu S.-M., Chen S.-K., Kao F.Y., Lin S.-J.,
RA   Hsiao S.-H., Tseng I.C., Hsing Y.-I.C., Wu H.-P., Chen C.-S., Shaw J.-F.,
RA   Wu J., Matsumoto T., Sasaki T., Chen H.-C., Chow T.-Y.;
RT   "A fine physical map of the rice chromosome 5.";
RL   Mol. Genet. Genomics 274:337-345(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA   Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA   Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA   Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA   Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA   Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA   Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA   Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA   Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA   Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA   Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA   Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA   Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA   Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA   McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT   "The genomes of Oryza sativa: a history of duplications.";
RL   PLoS Biol. 3:266-281(2005).
RN   [6]
RP   GENE FAMILY.
RX   PubMed=17556508; DOI=10.1104/pp.107.101105;
RA   Shultz R.W., Tatineni V.M., Hanley-Bowdoin L., Thompson W.F.;
RT   "Genome-wide analysis of the core DNA replication machinery in the higher
RT   plants Arabidopsis and rice.";
RL   Plant Physiol. 144:1697-1714(2007).
CC   -!- FUNCTION: Probable component of the MCM2-7 complex (MCM complex) that
CC       may function as a DNA helicase and which is essential to undergo a
CC       single round of replication initiation and elongation per cell cycle in
CC       eukaryotic cells. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC   -!- SUBUNIT: Component of the minichromosome maintenance (MCM) complex, a
CC       heterotetramer composed of MCM2, MCM3, MCM4, MCM5, MCM6 and MCM7.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the MCM family. {ECO:0000305}.
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DR   EMBL; AC118286; AAT73631.1; -; Genomic_DNA.
DR   EMBL; AC136223; AAT93993.1; -; Genomic_DNA.
DR   EMBL; AP008211; BAF16903.1; -; Genomic_DNA.
DR   EMBL; AP014961; BAS92939.1; -; Genomic_DNA.
DR   EMBL; CM000142; EEE62921.1; -; Genomic_DNA.
DR   RefSeq; XP_015638050.1; XM_015782564.1.
DR   AlphaFoldDB; Q6F353; -.
DR   SMR; Q6F353; -.
DR   STRING; 4530.OS05T0235800-01; -.
DR   PaxDb; Q6F353; -.
DR   PRIDE; Q6F353; -.
DR   EnsemblPlants; Os05t0235800-01; Os05t0235800-01; Os05g0235800.
DR   GeneID; 4338176; -.
DR   Gramene; Os05t0235800-01; Os05t0235800-01; Os05g0235800.
DR   KEGG; osa:4338176; -.
DR   eggNOG; KOG0480; Eukaryota.
DR   HOGENOM; CLU_000995_3_2_1; -.
DR   InParanoid; Q6F353; -.
DR   OMA; KYYIAQI; -.
DR   OrthoDB; 266497at2759; -.
DR   PlantReactome; R-OSA-9640882; Assembly of pre-replication complex.
DR   PlantReactome; R-OSA-9645850; Activation of pre-replication complex.
DR   PlantReactome; R-OSA-9675824; DNA replication Initiation.
DR   Proteomes; UP000000763; Chromosome 5.
DR   Proteomes; UP000007752; Chromosome 5.
DR   Proteomes; UP000059680; Chromosome 5.
DR   Genevisible; Q6F353; OS.
DR   GO; GO:0042555; C:MCM complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003697; F:single-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006268; P:DNA unwinding involved in DNA replication; IBA:GO_Central.
DR   GO; GO:0000727; P:double-strand break repair via break-induced replication; IBA:GO_Central.
DR   GO; GO:1902969; P:mitotic DNA replication; IBA:GO_Central.
DR   Gene3D; 2.40.50.140; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR031327; MCM.
DR   InterPro; IPR008049; MCM6.
DR   InterPro; IPR041024; Mcm6_C.
DR   InterPro; IPR018525; MCM_CS.
DR   InterPro; IPR001208; MCM_dom.
DR   InterPro; IPR041562; MCM_lid.
DR   InterPro; IPR027925; MCM_N.
DR   InterPro; IPR033762; MCM_OB.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11630; PTHR11630; 1.
DR   Pfam; PF00493; MCM; 1.
DR   Pfam; PF18263; MCM6_C; 1.
DR   Pfam; PF17855; MCM_lid; 1.
DR   Pfam; PF14551; MCM_N; 1.
DR   Pfam; PF17207; MCM_OB; 1.
DR   PRINTS; PR01657; MCMFAMILY.
DR   PRINTS; PR01662; MCMPROTEIN6.
DR   SMART; SM00350; MCM; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00847; MCM_1; 1.
DR   PROSITE; PS50051; MCM_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell cycle; DNA replication; DNA-binding; Helicase; Hydrolase;
KW   Metal-binding; Nucleotide-binding; Nucleus; Reference proteome; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..830
FT                   /note="DNA replication licensing factor MCM6"
FT                   /id="PRO_0000425997"
FT   DOMAIN          349..555
FT                   /note="MCM"
FT   ZN_FING         159..186
FT                   /note="C4-type"
FT                   /evidence="ECO:0000255"
FT   REGION          671..710
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           531..534
FT                   /note="Arginine finger"
FT   BINDING         399..406
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   830 AA;  92513 MW;  25688B473EB7536C CRC64;
     MEAFGGFFVD EKAARVENIF LEFLRRFKEA DAAEAFYETE LEAMRSREST TMYVDFAHVM
     RFNDVLQKAI SEEYLRFEPY LRNACKRFVM EQRTGENRAP IISDDSPNKD INIAFYNIPM
     LKRLRELGTA EIGKLTAVMG VVTRTSEVRP ELLQGTFKCL DCGNVVKNVE QQFKYTEPII
     CVNATCQNRS KWALLRQESK FTDWQRVRMQ ETSKEIPAGS LPRSLDVILR HEIVEKARAG
     DTVIFTGTVV AVPDVMALTS PGERAECRRE APQRKNGSGV QEGVKGLKSL GVRDLSYRLA
     FVANSVQVAD GRREVDIRDR DIDGDDSERQ KFTEEEEDEV VRMRNVPDFF NKIVDSICPT
     VFGHQEIKRA ILLMLLGGVH KITHEGINLR GDINVCIVGD PSCAKSQFLK YTAGIVPRSV
     YTSGKSSSAA GLTATVAKEP ETGEFCIEAG ALMLADNGIC CIDEFDKMDI KDQVAIHEAM
     EQQTISITKA GIQATLNART SILAAANPTG GRYDKSKPLK YNVALPPAIL SRFDLVYIMI
     DEPDENTDYH IAHHIVRVHQ KREEALAPAF STAELKRYIA FAKSLKPQLS SEAKKVLVES
     YVTLRRGDST PGTRVAYRMT VRQLEALIRL SEAIARSHLE RVVLPAHVRM AVKLLKTSII
     SVESSEVDLS DFQDADDGTN VPADNDAGQP TEMDAAPQQD GPENEQAADT GKKKLVITEE
     HFQRVTQALV MRLRQHEESV TKDGDGLAGM KQGDLIIWYV EQQNAQGAYS STAEVKEEVK
     CIKAIIERLI QRDGHLIVID EGAAPAADDG AARRTSESRI LAVNPNYVID