MCM7_ORYSI
ID MCM7_ORYSI Reviewed; 725 AA.
AC B8BMI1;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 1.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=DNA replication licensing factor MCM7;
DE EC=3.6.4.12;
DE AltName: Full=Minichromosome maintenance protein 7;
GN Name=MCM7; ORFNames=OsI_38725;
OS Oryza sativa subsp. indica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39946;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. 93-11;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
CC -!- FUNCTION: Probable component of the MCM2-7 complex (MCM complex) that
CC may function as a DNA helicase and which is essential to undergo a
CC single round of replication initiation and elongation per cell cycle in
CC eukaryotic cells. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC -!- SUBUNIT: Component of the minichromosome maintenance (MCM) complex, a
CC heterotetramer composed of MCM2, MCM3, MCM4, MCM5, MCM6 and MCM7.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the MCM family. {ECO:0000305}.
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DR EMBL; CM000137; EEC69501.1; -; Genomic_DNA.
DR AlphaFoldDB; B8BMI1; -.
DR SMR; B8BMI1; -.
DR STRING; 39946.B8BMI1; -.
DR EnsemblPlants; BGIOSGA036008-TA; BGIOSGA036008-PA; BGIOSGA036008.
DR Gramene; BGIOSGA036008-TA; BGIOSGA036008-PA; BGIOSGA036008.
DR HOGENOM; CLU_000995_7_2_1; -.
DR OMA; NAYTCDR; -.
DR Proteomes; UP000007015; Chromosome 12.
DR GO; GO:0000785; C:chromatin; IEA:EnsemblPlants.
DR GO; GO:0005737; C:cytoplasm; IEA:EnsemblPlants.
DR GO; GO:0042555; C:MCM complex; IEA:InterPro.
DR GO; GO:0000347; C:THO complex; IEA:EnsemblPlants.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR GO; GO:0009555; P:pollen development; IEA:EnsemblPlants.
DR GO; GO:0090329; P:regulation of DNA-templated DNA replication; IEA:EnsemblPlants.
DR CDD; cd17758; MCM7; 1.
DR Gene3D; 2.40.50.140; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR008050; MCM7.
DR InterPro; IPR018525; MCM_CS.
DR InterPro; IPR001208; MCM_dom.
DR InterPro; IPR041562; MCM_lid.
DR InterPro; IPR027925; MCM_N.
DR InterPro; IPR033762; MCM_OB.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11630; PTHR11630; 1.
DR PANTHER; PTHR11630:SF26; PTHR11630:SF26; 1.
DR Pfam; PF00493; MCM; 1.
DR Pfam; PF17855; MCM_lid; 1.
DR Pfam; PF14551; MCM_N; 1.
DR Pfam; PF17207; MCM_OB; 1.
DR PRINTS; PR01657; MCMFAMILY.
DR PRINTS; PR01663; MCMPROTEIN7.
DR SMART; SM00350; MCM; 1.
DR SUPFAM; SSF50249; SSF50249; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00847; MCM_1; 1.
DR PROSITE; PS50051; MCM_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cell cycle; DNA replication; DNA-binding; Helicase; Hydrolase;
KW Nucleotide-binding; Nucleus; Reference proteome.
FT CHAIN 1..725
FT /note="DNA replication licensing factor MCM7"
FT /id="PRO_0000426000"
FT DOMAIN 333..538
FT /note="MCM"
FT MOTIF 515..518
FT /note="Arginine finger"
FT BINDING 383..390
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
SQ SEQUENCE 725 AA; 81319 MW; 02E50E00F1CB15E3 CRC64;
MAATATKTID FAAERALAKD FLANFAGPRG EPKYLNILQD VANRKIRAVQ IELDDLFHYK
DADDEFLQRV TENTKRYIGI FADAIDELMP ESTEAYAVDE DRDILMTQRV DEGADGGADG
TDPLQRMPPE IRRFFEVYIK AFSKVTPLTI RQVKASNIGQ LVKISGIVTR CSDVKPLMQV
AVYTCEECGF EIYQEVTARV FMPLFECPSQ RCKLNKAKGN LILQLRASKF LKFQEVKLQE
LAEHVPKGHI PRSLTVHLRG ELTRKVAPGD VVEMSGIFLP MPYYGFRAMR AGLVADTYLE
SMSITHFKKK YEEYELKGDE QEQIDRLAED GDIYNKLARS LAPEIFGHED VKKALLLLLV
GAPHRKLTDG MKIRGDLHIC LMGDPGVAKS QLLKHIINVA PRGVYTTGRG SSGVGLTAAV
QKDPVTNEFV LEGGALVLAD MGICAIDEFD KMEESDRTAI HEVMEQQTVS IAKAGITTSL
NARTAVLAAA NPAWGRYDMR RTPAENINLP PALLSRFDLL WLILDRADME TDLEMARHVV
HVHQNLESPA LGFTPLEPPV LRAYISAARR VVPSVPRELE EYIATAYSSI RQEEAKSNAP
HSYTTIRTLL SILRISIALA RLRFSETVAQ SDVDEALRLM QMSKYSLYSD DRQRSGLDAI
SDIYSILRDE AARTNSMDVR YAHALNLISR KGYSEAQLKE CLEEYASLNV WQIHPNTFDI
HFIDA
