ID   MCM7_ORYSJ              Reviewed;         725 AA.
AC   Q2QNM1; A0A0P0YBD7; B7EM47;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 138.
DE   RecName: Full=DNA replication licensing factor MCM7;
DE            EC=3.6.4.12;
DE   AltName: Full=Minichromosome maintenance protein 7;
DE            Short=OsMCM7;
GN   Name=MCM7; OrderedLocusNames=Os12g0560700, LOC_Os12g37400;
GN   ORFNames=OsJ_36507;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16188032; DOI=10.1186/1741-7007-3-20;
RG   The rice chromosomes 11 and 12 sequencing consortia;
RT   "The sequence of rice chromosomes 11 and 12, rich in disease resistance
RT   genes and recent gene duplications.";
RL   BMC Biol. 3:20-20(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA   Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA   Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA   Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA   Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA   Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA   Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA   Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA   Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA   Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA   Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA   Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA   Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA   Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA   McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT   "The genomes of Oryza sativa: a history of duplications.";
RL   PLoS Biol. 3:266-281(2005).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
RN   [7]
RP   GENE FAMILY.
RX   PubMed=17556508; DOI=10.1104/pp.107.101105;
RA   Shultz R.W., Tatineni V.M., Hanley-Bowdoin L., Thompson W.F.;
RT   "Genome-wide analysis of the core DNA replication machinery in the higher
RT   plants Arabidopsis and rice.";
RL   Plant Physiol. 144:1697-1714(2007).
CC   -!- FUNCTION: Probable component of the MCM2-7 complex (MCM complex) that
CC       may function as a DNA helicase and which is essential to undergo a
CC       single round of replication initiation and elongation per cell cycle in
CC       eukaryotic cells. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC   -!- SUBUNIT: Component of the minichromosome maintenance (MCM) complex, a
CC       heterotetramer composed of MCM2, MCM3, MCM4, MCM5, MCM6 and MCM7.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the MCM family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAG93444.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; DP000011; ABA98932.1; -; Genomic_DNA.
DR   EMBL; AP008218; BAF30039.1; -; Genomic_DNA.
DR   EMBL; AP014968; BAT17641.1; -; Genomic_DNA.
DR   EMBL; CM000149; EEE53429.1; -; Genomic_DNA.
DR   EMBL; AK073411; BAG93444.1; ALT_INIT; mRNA.
DR   RefSeq; XP_015618828.1; XM_015763342.1.
DR   AlphaFoldDB; Q2QNM1; -.
DR   SMR; Q2QNM1; -.
DR   STRING; 4530.OS12T0560700-01; -.
DR   PaxDb; Q2QNM1; -.
DR   PRIDE; Q2QNM1; -.
DR   EnsemblPlants; Os12t0560700-01; Os12t0560700-01; Os12g0560700.
DR   GeneID; 4352514; -.
DR   Gramene; Os12t0560700-01; Os12t0560700-01; Os12g0560700.
DR   KEGG; osa:4352514; -.
DR   eggNOG; KOG0482; Eukaryota.
DR   HOGENOM; CLU_000995_7_2_1; -.
DR   InParanoid; Q2QNM1; -.
DR   OMA; NAYTCDR; -.
DR   OrthoDB; 266497at2759; -.
DR   PlantReactome; R-OSA-9640882; Assembly of pre-replication complex.
DR   PlantReactome; R-OSA-9645850; Activation of pre-replication complex.
DR   PlantReactome; R-OSA-9675824; DNA replication Initiation.
DR   Proteomes; UP000000763; Chromosome 12.
DR   Proteomes; UP000007752; Chromosome 12.
DR   Proteomes; UP000059680; Chromosome 12.
DR   Genevisible; Q2QNM1; OS.
DR   GO; GO:0000785; C:chromatin; IEA:EnsemblPlants.
DR   GO; GO:0005737; C:cytoplasm; IEA:EnsemblPlants.
DR   GO; GO:0042555; C:MCM complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000347; C:THO complex; IEA:EnsemblPlants.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0003697; F:single-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0006270; P:DNA replication initiation; IBA:GO_Central.
DR   GO; GO:0006271; P:DNA strand elongation involved in DNA replication; IBA:GO_Central.
DR   GO; GO:0006268; P:DNA unwinding involved in DNA replication; IBA:GO_Central.
DR   GO; GO:0000727; P:double-strand break repair via break-induced replication; IBA:GO_Central.
DR   GO; GO:0009555; P:pollen development; IEA:EnsemblPlants.
DR   GO; GO:0090329; P:regulation of DNA-templated DNA replication; IEA:EnsemblPlants.
DR   CDD; cd17758; MCM7; 1.
DR   Gene3D; 2.40.50.140; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR031327; MCM.
DR   InterPro; IPR008050; MCM7.
DR   InterPro; IPR018525; MCM_CS.
DR   InterPro; IPR001208; MCM_dom.
DR   InterPro; IPR041562; MCM_lid.
DR   InterPro; IPR027925; MCM_N.
DR   InterPro; IPR033762; MCM_OB.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11630; PTHR11630; 1.
DR   PANTHER; PTHR11630:SF26; PTHR11630:SF26; 1.
DR   Pfam; PF00493; MCM; 1.
DR   Pfam; PF17855; MCM_lid; 1.
DR   Pfam; PF14551; MCM_N; 1.
DR   Pfam; PF17207; MCM_OB; 1.
DR   PRINTS; PR01657; MCMFAMILY.
DR   PRINTS; PR01663; MCMPROTEIN7.
DR   SMART; SM00350; MCM; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00847; MCM_1; 1.
DR   PROSITE; PS50051; MCM_2; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Cell cycle; DNA replication; DNA-binding; Helicase; Hydrolase;
KW   Nucleotide-binding; Nucleus; Reference proteome.
FT   CHAIN           1..725
FT                   /note="DNA replication licensing factor MCM7"
FT                   /id="PRO_0000425999"
FT   DOMAIN          333..538
FT                   /note="MCM"
FT   MOTIF           515..518
FT                   /note="Arginine finger"
FT   BINDING         383..390
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   725 AA;  81349 MW;  D432D570EC7DC774 CRC64;
     MAATATKTID FAAERALAKD FLANFAGPRG EPKYLNILQD VANRKIRAVQ IELDDLFHYK
     DADDEFLQRV TENTKRYIGI FADAIDELMP ESTEAYAVDE DRDILMTQRV DEGADGGADG
     TDPLQRMPPE IRRFFEVYIK AFSKVTPLTI RQVKASNIGQ LVKISGIVTR CSDVKPLMQV
     AVYTCEECGF EIYQEVTARV FMPLFECPSQ RCKLNKAKGN LILQLRASKF LKFQEVKLQE
     LAEHVPKGHI PRSLTVHLRG ELTRKVAPGD VVEMSGIFLP MPYYGFRAMR AGLVADTYLE
     SMSITHFKKK YEEYELKGDE QEQIDRLAED GDIYNKLARS LAPEIFGHED VKKALLLLLV
     GAPHRKLTDG MKIRGDLHIC LMGDPGVAKS QLLKHIINVA PRGVYTTGRG SSGVGLTAAV
     QKDPVTNEFV LEGGALVLAD MGICAIDEFD KMEESDRTAI HEVMEQQTVS IAKAGITTSL
     NARTAVLAAA NPAWGRYDMR RTPAENINLP PALLSRFDLL WLILDRADME TDLEMARHVV
     HVHQNLESPA LGFTPLEPPV LRAYISTARR VVPSVPRELE EYIATAYSSI RQEEAKSNAP
     HSYTTIRTLL SILRISIALA RLRFSETVAQ SDVDEALRLM QMSKYSLYSD DRQRSGLDAI
     SDIYSILRDE AARTNSMDVR YAHALNLISR KGYSEAQLKE CLEEYASLNV WQIHPNTFDI
     HFIDA