MCM8_ORYSI
ID MCM8_ORYSI Reviewed; 789 AA.
AC B8AZ14;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 1.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=Probable DNA helicase MCM8;
DE EC=3.6.4.12;
DE AltName: Full=Minichromosome maintenance 8;
GN Name=MCM8; ORFNames=OsI_20256;
OS Oryza sativa subsp. indica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39946;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. 93-11;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
CC -!- FUNCTION: Probable DNA helicase that may play a role in DNA repair
CC durin meiosis. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the MCM family. {ECO:0000305}.
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DR EMBL; CM000130; EEC79367.1; -; Genomic_DNA.
DR AlphaFoldDB; B8AZ14; -.
DR SMR; B8AZ14; -.
DR STRING; 39946.B8AZ14; -.
DR EnsemblPlants; BGIOSGA020002-TA; BGIOSGA020002-PA; BGIOSGA020002.
DR Gramene; BGIOSGA020002-TA; BGIOSGA020002-PA; BGIOSGA020002.
DR HOGENOM; CLU_000995_7_2_1; -.
DR OMA; THTVDWQ; -.
DR Proteomes; UP000007015; Chromosome 5.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:EnsemblPlants.
DR GO; GO:0007143; P:female meiotic nuclear division; IEA:EnsemblPlants.
DR GO; GO:0007140; P:male meiotic nuclear division; IEA:EnsemblPlants.
DR GO; GO:0009555; P:pollen development; IEA:EnsemblPlants.
DR Gene3D; 2.40.50.140; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR018525; MCM_CS.
DR InterPro; IPR001208; MCM_dom.
DR InterPro; IPR041562; MCM_lid.
DR InterPro; IPR033762; MCM_OB.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11630; PTHR11630; 1.
DR Pfam; PF00493; MCM; 1.
DR Pfam; PF17855; MCM_lid; 1.
DR Pfam; PF17207; MCM_OB; 1.
DR PRINTS; PR01657; MCMFAMILY.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00350; MCM; 1.
DR SUPFAM; SSF50249; SSF50249; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00847; MCM_1; 1.
DR PROSITE; PS50051; MCM_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Helicase; Hydrolase;
KW Meiosis; Metal-binding; Nucleotide-binding; Nucleus; Reference proteome;
KW Zinc; Zinc-finger.
FT CHAIN 1..789
FT /note="Probable DNA helicase MCM8"
FT /id="PRO_0000426003"
FT DOMAIN 339..546
FT /note="MCM"
FT ZN_FING 174..201
FT /note="C4-type"
FT /evidence="ECO:0000255"
FT MOTIF 522..525
FT /note="Arginine finger"
FT BINDING 391..398
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
SQ SEQUENCE 789 AA; 86273 MW; 674A963EA6DD5F6A CRC64;
MYDDGPRKGK PGGLSMDAAT AAGLAAVWPE YFPEESEFAA DGRSARLAAD LVDLFSSPDA
SDLLSRVEDD GDILSLPVDF QQLSNLTWIT EALQENPKEA LLSMGAAVHL IVCASRDLQL
GDINKINIRL YNHTKTIALK NLKAAYIKKL VTVRGTVLKV STVKPLVLQL NFQCMKCATK
FPRVFCDGKF SPPVSCSIQG CKSRTFIPMR STAKLMDFQK IRIQELASGE SHEEGRVPRT
IECELTEDLV DCCIPGETVT VTGIVKVLNN YMDVGGGKSK SRNQGLYYLY LEAISVRNSK
VHAASGNSDA ASGSFGFQAF TEKDLEFISK FKEEHGADVF RQILHSFCPS IYGHELVKAG
ITLALFGGVQ KHSIDQNKVP VRGDIHAVVV GDPGLGKSQL LQAAAAVSPR GIYVCGNTTT
NAGLTVAVVK DSMSNDYAFE AGAMVLADRG ICCIDEFDKM SAEHQALLEA MEQQCVSVAK
AGLVASLSAR TSVLAAANPV GGHYDRAKTV NENLKMSAAL LSRFDLVFIL LDKPDELLDK
RVSDHIIALH SNDGGPFTAN KRIRTVPQFN PSTEFGVGRT SLASRLRLHP EKDKDFCPLP
GPLLRKYISY ARSHVNPRIF MPSPAADSLQ KFYLDLRKQS DSADGTPITA RQLESLVRLA
EARARVDLRE EVTLEDAKEV IDIMTESLYD KCVDEHGVVD FARSGGMSNQ KQSKKFLRAL
NEQCDLQKKD CFTMNEMYNL ADRISLQVAN LDAIVESLNN AGYITKKGSS MYQVVTSSYQ
GSQATWSGR
