MCM9_ARATH
ID MCM9_ARATH Reviewed; 646 AA.
AC F4IFF3; Q9ZPT4;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 65.
DE RecName: Full=Probable DNA helicase MCM9;
DE EC=3.6.4.12;
DE AltName: Full=Minichromosome maintenance 9;
DE Short=AtMCM9;
GN Name=MCM9; OrderedLocusNames=At2g14050; ORFNames=F9B22;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY.
RX PubMed=17556508; DOI=10.1104/pp.107.101105;
RA Shultz R.W., Tatineni V.M., Hanley-Bowdoin L., Thompson W.F.;
RT "Genome-wide analysis of the core DNA replication machinery in the higher
RT plants Arabidopsis and rice.";
RL Plant Physiol. 144:1697-1714(2007).
CC -!- FUNCTION: Probable DNA helicase that may play a role in DNA repair
CC during meiosis. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the MCM family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD19787.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC006528; AAD19787.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; ANM63022.1; -; Genomic_DNA.
DR PIR; E84513; E84513.
DR RefSeq; NP_179021.3; NM_126977.4.
DR AlphaFoldDB; F4IFF3; -.
DR SMR; F4IFF3; -.
DR BioGRID; 1250; 1.
DR STRING; 3702.AT2G14050.1; -.
DR PaxDb; F4IFF3; -.
DR PRIDE; F4IFF3; -.
DR ProteomicsDB; 250832; -.
DR EnsemblPlants; AT2G14050.2; AT2G14050.2; AT2G14050.
DR GeneID; 815890; -.
DR Gramene; AT2G14050.2; AT2G14050.2; AT2G14050.
DR KEGG; ath:AT2G14050; -.
DR Araport; AT2G14050; -.
DR TAIR; locus:2053448; AT2G14050.
DR eggNOG; KOG0477; Eukaryota.
DR HOGENOM; CLU_000995_7_2_1; -.
DR InParanoid; F4IFF3; -.
DR PRO; PR:F4IFF3; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; F4IFF3; baseline and differential.
DR Genevisible; F4IFF3; AT.
DR GO; GO:0042555; C:MCM complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003697; F:single-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IBA:GO_Central.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR Gene3D; 2.40.50.140; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR001208; MCM_dom.
DR InterPro; IPR041562; MCM_lid.
DR InterPro; IPR033762; MCM_OB.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11630; PTHR11630; 1.
DR Pfam; PF00493; MCM; 1.
DR Pfam; PF17855; MCM_lid; 1.
DR Pfam; PF17207; MCM_OB; 1.
DR PRINTS; PR01657; MCMFAMILY.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00350; MCM; 1.
DR SUPFAM; SSF50249; SSF50249; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50051; MCM_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Helicase; Hydrolase;
KW Meiosis; Metal-binding; Nucleotide-binding; Nucleus; Reference proteome;
KW Zinc; Zinc-finger.
FT CHAIN 1..646
FT /note="Probable DNA helicase MCM9"
FT /id="PRO_0000426004"
FT DOMAIN 308..511
FT /note="MCM"
FT ZN_FING 155..188
FT /note="C4-type"
FT /evidence="ECO:0000255"
FT MOTIF 487..490
FT /note="Arginine finger"
FT BINDING 358..365
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
SQ SEQUENCE 646 AA; 72463 MW; EFDCD58792373227 CRC64;
MESPTQTSEH IESMTEFLVK HYPDQLREIS LSSDPKLHYP LFIEYAELVD DNPSLARQVF
SDPEHYLRQF DDSAILAHKI ALEHMKKFEE KIGIEKRFIH VRINTSGSPL ERSPETFPSI
GRVRVKHRGI LMMLKGTVIR SGAVKMYEGE KMYRCRKCKH MFPIFPELES INSIVKPPFC
PSQRSKACEG TNFDPVDDTV TRHDYQEIKI QENTQVLGVG VIPRSILVVL KDDLVDNVKA
GDDVVVSGIL TSKWSHDLKD VRCDLEPMLI ANHVRRTNEL KSEIDISDDL IEKFKNFWSH
FRDTPLKGRN AILRGICPQV FGLFTVKLAV ALTLIGGVQH VDASGTKVRG ESHLLLIGDP
GTGKSQFLKF AAKLSNRAVI TTGLGSTSAG LTVTAVKDGG EWMLEAGALV LADGGLCCID
EFDSMREHDR ATIHEAMEQQ SISVAKAGLV TTLSTKTIVF GATNPKGQYD PDQSLSVNTA
LSGPLLSRFD IVLVLLDTKN PEWDAVVSSH ILAEVQIEQD REVDDLTTIW PLPMLQRYIQ
FVKKNFRPVL SKEAEEIISS YYRLQRRSST HNAARTTVRM LESLIRLAQA HARLMFRNEV
TRLDAITAIL CIESSMTISA IVDSMGNALH SNFSEEPDQE CILFRH
